RESUMO
Two new 5-methylcoumarin glycosides named diosfeboside A (1) and B (2) and five known compounds namely kaempferol 3-O-α-L-rhamnopyranosyl-(1 â 2)-ß-D-glucopyranoside (3), ursolic acid (4), betulinic acid (5), stigmasterol (6) and stigmasterol 3-O-ß-D-glucopyranoside (7) were isolated from the leaves of Diospyros crassiflora (Hiern). Their structures were established through interpretation of 1 and 2D NMR, mass spectra analysis and comparison with reported data. In vitro cytotoxic activity of the new compounds against human carcinoma cell lines (HL-60, Bel-7402, BGC-823, and KB) was evaluated and no cytotoxicity was observed for each of them.
Assuntos
Cumarínicos/isolamento & purificação , Diospyros/química , Glicosídeos/isolamento & purificação , Extratos Vegetais/química , Linhagem Celular Tumoral , Cumarínicos/química , Cumarínicos/farmacologia , Glicosídeos/química , Glicosídeos/farmacologia , Humanos , Estrutura Molecular , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Folhas de PlantaRESUMO
Ten triterpenoid glycosides, including five new ones (1-5), were isolated from the leaves of Ilex pernyi. The chemical structures of 1-5 were determined on the basis of the chemical and spectroscopic evidence.
Assuntos
Glicosídeos/química , Ilex/química , Extratos Vegetais/química , Folhas de Planta/química , Triterpenos/química , Medicamentos de Ervas Chinesas , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
OBJECTIVE: To study the characters of concentration of 42 elements in Radix Astragali and make an attempt at looking for relationship between the element concentration and regions where samplers are obtained. METHOD: Determining the content of elements in 40 Radix Astragali samples from 7 different provinces by ICP-MS, AFS and ASS. Analyzing the correlation of elements in Radix Astragali using statistic software (Spss). RESULT: Firstly, similar lines of element concentration have been acquired in our research. Secondly, it is observed that the content of elements in the samples shows regional diversity. Thirdly, there are 346 correlative element pairs in correlate analysis. And some of them indicate remarkable correlativity. CONCLUSION: With the aid of obtained results, it is concluded that element content in Radix Astragali display special distributing line. Remarkable correlation is presented in some element pairs. The quality of Radix Astragali gained from Neimeng, Shanxi and Gansu are better than those from other regions.
Assuntos
Astrágalo/química , Astrágalo/crescimento & desenvolvimento , China , Elementos Químicos , GeografiaRESUMO
A new compound and five known compounds were isolated from the ethanolic extract of the leaves of Ilex pernyi Franch. Their structures were established on the basis of spectral analysis and identified as trans-isoeugenyl-alpha-L-arabinopynosyl (1 --> 6) -beta-D-glucopyranoside (1) , kaempferol-3-O-sambubioside (2), quercetin-3-O-sambubioside (3), isoquercitrin (4), (+) -syringaresinol-O-beta-D-glucopyranoside (5), amarantholidoside IV (6). Among them, compound 1 is a new phenolic glycoside, named as ilexperphenoside A, and compounds 2-6 were isolated from this plant for the first time.
Assuntos
Glucosídeos/isolamento & purificação , Ilex/química , Quercetina/análogos & derivados , Glucosídeos/química , Glicosídeos/química , Glicosídeos/isolamento & purificação , Estrutura Molecular , Folhas de Planta/química , Plantas Medicinais/química , Quercetina/química , Quercetina/isolamento & purificaçãoRESUMO
OBJECTIVE: To investigate the chemical constituents of the aerial parts of Ammopiptanthus mongolicus. METHOD: The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. RESULT: Ten compounds were isolated and identified as m-hydroxybenzoic acid (1), 1-(4-hydroxyphenyl) ethanone (2), beta-sitosterol (3), (-)-syringaresinol (4), (+)-lariciresinol (5), blumenol A (6), blumenol B (7), beta-daucosterol (8), coniferin (9), syringin (10). CONCLUSION: The ten compounds were obtained from the genus Ammopiptanthus for the first time.
Assuntos
Medicamentos de Ervas Chinesas/química , Fabaceae/química , Componentes Aéreos da Planta/química , Cinamatos/química , Cicloexanonas/química , Glucosídeos/química , Espectroscopia de Ressonância Magnética , Fenilpropionatos/química , Sitosteroides/químicaRESUMO
OBJECTIVE: To investigate the chemical constituents of Ilex pernyi. METHOD: The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. RESULT: Eight triterpenoid compounds were isolated and identified as ursolic acid (1), lupeol (2), alpha-amyrin (3), uvaol (4), 3beta-hydroxyurs-11-ene-13beta-olide (5), pomolic acid (6), lup-20 (29)-ene-3beta, 24-diol (7), 3beta, 23-dihydroxy-urs-12-en-28-oic acid (8). CONCLUSION: The eight compounds were obtained from this plant for the first time.
Assuntos
Ilex/química , Ácido Oleanólico/análogos & derivados , Triterpenos/isolamento & purificação , Ácido Oleanólico/química , Ácido Oleanólico/isolamento & purificação , Folhas de Planta/química , Plantas Medicinais/química , Triterpenos/química , Ácido UrsólicoRESUMO
Ilexpernoside A and ilexpernoside B, two new pentacyclic C(4)-nortriterpenoid saponins, were isolated from the leaves of Ilex pernyi Franch. Their chemical structures were determined by MS, NMR spectroscopy and chemical analysis. Complete assignments of the (1)H and (13)C NMR spectroscopic data were achieved by 1D and 2D NMR experiments (HSQC, HMBC, (1)H-(1)H COSY and NOESY).
