Evaluation of Task fMRI Decoding With Deep Learning on a Small Sample Dataset.

Recently, several deep learning methods have been applied to decoding in task-related fMRI, and their advantages have been exploited in a variety of ways. However, this paradigm is sometimes problematic, due to the difficulty of applying deep learning to high-dimensional data and small sample size conditions. The difficulties in gathering a large amount of data to develop predictive machine learning models with multiple layers from fMRI experiments with complicated designs and tasks are well-recognized. Group-level, multi-voxel pattern analysis with small sample sizes results in low statistical power and large accuracy evaluation errors; failure in such instances is ascribed to the individual variability that risks information leakage, a particular issue when dealing with a limited number of subjects. In this study, using a small-size fMRI dataset evaluating bilingual language switch in a property generation task, we evaluated the relative fit of different deep learning models, incorporating moderate split methods to control the amount of information leakage. Our results indicated that using the session shuffle split as the data folding method, along with the multichannel 2D convolutional neural network (M2DCNN) classifier, recorded the best authentic classification accuracy, which outperformed the efficiency of 3D convolutional neural network (3DCNN). In this manuscript, we discuss the tolerability of within-subject or within-session information leakage, of which the impact is generally considered small but complex and essentially unknown; this requires clarification in future studies.

Using a Data-Driven Approach to Estimate Second-Language Proficiency From Brain Activation: A Functional Near-Infrared Spectroscopy Study.

While non-invasive brain imaging has made substantial contributions to advance human brain science, estimation of individual state is becoming important to realize its applications in society. Brain activations were used to classify second-language proficiencies. Participants in functional near-infrared spectroscopy (fNIRS) experiment were 20/20 native Japanese speakers with high/low English abilities and 19/19 native English speakers with high/low Japanese abilities. Their cortical activities were measured by functional near-infrared spectroscopy while they were conducting Japanese/English listening comprehension tests. The data-driven method achieved classification accuracy of 77.5% in the case of Japanese speakers and 81.9% in the case of English speakers. The informative features predominantly originated from regions associated with language function. These results bring an insight of fNIRS neuroscience and its applications in society.

Neural basis of language switching in the brain: fMRI evidence from Korean-Chinese early bilinguals.

Using fMRI, we conducted two types of property generation task that involved language switching, with early bilingual speakers of Korean and Chinese. The first is a more conventional task in which a single language (L1 or L2) was used within each trial, but switched randomly from trial to trial. The other consists of a novel experimental design where language switching happens within each trial, alternating in the direction of the L1/L2 translation required. Our findings support a recently introduced cognitive model, the 'hodological' view of language switching proposed by Moritz-Gasser and Duffau. The nodes of a distributed neural network that this model proposes are consistent with the informative regions that we extracted in this study, using both GLM methods and Multivariate Pattern Analyses: the supplementary motor area, caudate, supramarginal gyrus and fusiform gyrus and other cortical areas.