1.
Org Biomol Chem
; 21(37): 7535-7540, 2023 Sep 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37674436
RESUMO
A concise approach to the construction of the 2-pyrrolin-5-one scaffold was developed via a one-pot reaction with formal [3 + 2] annulation/elimination between ß-keto nitrile/ß-keto ester and unsubstituted α-halohydroxamates. This reaction features mild conditions, easy handling, broad substrate scope and good yields. Remarkably, the products could be readily converted into potentially bioactive alkylidenepyrrolinones, pyrroles, pyran-fused pyrrole heterocycles and other useful compounds, exhibiting versatile synthetic potential.