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Biotechnol Lett ; 28(22): 1811-5, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16912920

RESUMO

Batch fermentation by Streptomyces pristinaespiralis with the addition of adsorbent resins was used to increase the production of pristinamycin. In consideration of the adsorption capacity and the desorption ability, a polymeric resin, JD-1, was finally selected. The maximum production of pristinamycin in Erlenmeyer flasks went up to 1.13 from 0.4 g l(-1), by adding 12% (w/v) resin JD-1 into the culture broth at 20 h after inoculation. In a 3 l bioreactor, pristinamycin fermentation with the addition of 12% (w/v) resin JD-1 at 20 h after inoculation reached 0.8 g l(-1), which was a 1.25-fold increase over fermentation without resin.


Assuntos
Antibacterianos/biossíntese , Reatores Biológicos , Biotecnologia/métodos , Fermentação , Pristinamicina/biossíntese , Resinas Vegetais/química , Streptomyces/metabolismo , Adsorção , Antibacterianos/química , Bioquímica/métodos , Concentração de Íons de Hidrogênio , Mutação , Pristinamicina/química , Fatores de Tempo
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