Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015.

A large outbreak of Legionnaires' disease occurred at a California state prison in August 2015. We conducted environmental and epidemiological investigations to identify the most likely source of exposure and characterise morbidity. Sixty-four inmates had probable Legionnaires' disease; 14 had laboratory-confirmed legionellosis. Thirteen (17%) inmates were hospitalised; there were no deaths. Ill inmates were more likely to be ⩾65 years old (P < 0.01), have the chronic obstructive pulmonary disease (P < 0.01), diabetes mellitus (P = 0.02), hepatitis C infection (P < 0.01), or end-stage liver disease (P < 0.01). The case-patients were in ten housing units throughout the prison grounds. All either resided in or were near the central clinical building (for appointments or yard time) during their incubation periods. Legionella pneumophila serogroup 1 was cultured from three cooling towers on top of the central medical clinic (range, 880-1200 cfu/ml). An inadequate water management program, dense biofilm within the cooling towers, and high ambient temperatures preceding the outbreak created an ideal environment for Legionella sp. proliferation. All state prisons were directed to develop local operating procedures for maintaining their cooling towers and the state health department added a review of the maintenance plans to their environmental inspection protocol.

Costs of hepatitis C.

OBJECTIVE: To estimate the direct and indirect costs of the hepatitis C virus (HCV) in the United States in 1997. DESIGN: Aggregation and analysis of national data sets collected by the National Center for Health Statistics, the Health Care Financing Administration, and other government bureaus and private firms. To estimate costs, we used the human capital method, which decomposes costs into direct categories, such as medical expenses, and indirect categories, such as lost earnings and lost home production. We consider HCV that results in chronic liver disease separate from HCV that results in primary liver cancer. RESULTS: We estimate $5.46 billion as the cost of HCV in 1997. Costs are split as follows: 33% for direct and 67% for indirect costs. Hepatitis C virus that results in chronic liver disease contributes roughly 92% of the costs, and HCV that results in primary liver cancer contributes the remaining 8%. The total estimate of $5.46 billion is conservative, because we ignore costs associated with pain and suffering and the value of care rendered by family members. CONCLUSIONS: To our knowledge, only one estimate of the annual costs of HCV in the 1990s has appeared in the literature, $0.6 billion. However, that estimate was not supported by an explanation of the methods. Our estimate, which relies on detailed methods, is nearly 10 times the original estimate. Our estimate of $5.46 billion is on a par with the cost of asthma ($5.8 billion [1994]).

Estimating the costs of job related arthritis.

OBJECTIVE: To present the first estimate of the costs of job related osteoarthritis (OA) in the USA. METHODS: Data were drawn from national data sets collected by the US Bureau of Labor Statistics, the US National Center for Health Statistics, and existing cost estimates for arthritis in the literature. We used proportional attributable risk (PAR) models to estimate the percentage of acute and repetitive injuries resulting in OA. These PAR vary between men and women. We used the human capital method that decomposes costs into direct categories such as medical expense and indirect categories such as lost earnings. RESULTS: We estimate job related OA costs US$3.41 to 13.23 billion per year (1994 dollars). Our point estimate is that job related OA contributes about 9% ($8.3 billion) to the total costs for all OA. About 51% of job related costs result from medical costs and 49% from lost productivity at work and at home. These costs are likely to underestimate the true burden since costs of pain and suffering as well as costs to family members and others who provide home care are ignored. CONCLUSION: The cost of job related arthritis is significant and has implications for both clinical and public policy. Depending on the PAR selected, job related arthritis is at least as costly as job related renal and neurological disease combined, and is on a par with the costs of job related chronic obstructive pulmonary disease and all asthma, whether job related or not.

Fire injuries, disasters, and costs from cigarettes and cigarette lights: a global overview.

BACKGROUND: Fires cause 1% of the global burden of disease. Fire (includes explosion) disasters have immense health, social, and environmental costs. We will provide initial estimates of overall U. S. and global fire tolls from smoking. METHODS: We tabulated and summarized smoking-related fire and disaster tolls from published documents. We compared those tolls to U.S. fire, burn, and fire death rates per billion cigarettes extrapolated globally. Smoking-attributable percentages of adult and child access to cigarette lighter and match ignitions (lights), and resultant fires, burns, and deaths ignited by young children, were estimated from likely smoking-attributable lights usage. Cigarette plus cigarette lights fire tolls were multiplied times published and estimated fire costs. RESULTS: Smoking is the leading cause of residential or total fire death in all eight countries with available statistics. Smoking is a leading cause of fires in many more countries. Cigarettes cause numerous fire disasters. Cigarette lights cause an estimated 100,000 U.S. and one million global, child-playing fires per year. Cigarette lights fire injuries likely rival U.S., and possibly global, cigarette fire injury numbers. Smoking causes an estimated 30% of U. S. and 10% of global fire death burdens. Smoking's estimated U.S. and global fire costs were $6.95 (sensitivity range $5.34-22.8) and $27.2 (sensitivity range $8.2-89.2) billion, respectively, in 1998 U. S. dollars. CONCLUSIONS: Smoking likely causes large global fire tolls. U.S. fire tolls have fallen when smoking decreased. Further reducing smoking can substantially reduce fire and disaster tolls.

Estimates of smoking-attributable deaths at ages 15-54, motherless or fatherless youths, and resulting Social Security costs in the United States in 1994.

BACKGROUND: Deaths of parents often harm their children, taxpayers, and society, for decades. So we estimated the smoking-attributable (SA) counts and percentages (SA%) of U.S. 1994 deaths at child-rearing ages; youths (ages <18) left motherless or fatherless; and resulting Social Security Survivors Insurance taxes. DESIGN: U.S. 1994 age/sex/education-specific total and SA death counts were estimated using death certificate data and standard CDC SAMMEC methods (with added injury mortality), respectively. We separately summed (a) total and (b) SA age/sex/education-specific death counts times their average number of youths per adult (cumulative fertility, adjusted for infant mortality). We then multiplied the SA and total bereft youth counts by their average duration of Survivors Insurance, and calculated the SA cost of youth Survivors Insurance. RESULTS: In 1994, smoking caused an estimated 44,000 male and 19,000 female U.S. deaths at ages 15-54, leaving 31,000 fatherless and 12,000 motherless youths. On December 31, 1994, the SA prevalences [count (SA%)] of fatherless or motherless youths were an estimated 220,000 (17%) and 86,000 (16%), respectively. Resulting Survivors Insurance costs were about $1.4 (sensitivity range: $0.58-3.7) billion in 1994. CONCLUSIONS: Smoking causes many U.S. deaths at ages 15-54, youth bereavements, and Survivors Insurance costs. Reductions in smoking may greatly reduce those deaths, bereavements, and taxpayer and societal costs.

Smoking as a risk factor for accident death: a meta-analysis of cohort studies.

This meta-analysis discusses the consistency, strength, dose-response, independence, and generalizability of published cohort data on accident death relative risks in smokers. To locate data, three authors independently searched MEDLINE, and bibliographies of the pertinent studies found, for data which allowed estimation of an appropriate cigarette smoker accident death relative risk (and 95% confidence interval). Relative risks and dose-response were summarized by fixed effects and Poisson modeling, respectively. Four pertinent cohort studies including eight populations were located. Cigarette smoking predicted summary accident death relative risks of 1.51 (95% confidence interval 1.27-1.78) versus never smokers and 1.35 (1.17-1.57) versus ex-smokers. Summary dose-response trends were significant (P = 0.0000) versus never or least smoking referents. In individual studies, the smoking/accident death association persisted after adjustment or, in effect stratification, for age, race, sex, and occupation; occupation and time period; or numerous cardiac risk factors. This meta-analysis found significant, consistent, dose-response, often strong and independent (of age, race, and sex), prospective associations of smoking with accident death, internationally. Further studies and warnings of the smoking/accident death associations seem merited.

The human and financial costs of smoking.

Smoking causes about 20% of United States adult deaths and numerous diseases. Health care for cancer, cardiovascular, and pulmonary diseases from smoking costs tens of billions of dollars per year. Yet those costs are likely far exceeded by costs from bereavement, lost productivity, pain and suffering, and health care for debilities from smoking. Though sometimes more difficult to precisely quantify than costs for fatalities, the lost productivity, suffering, or familial costs of smoking are often much larger, more immediate, and more understandable threats to smokers, their families, and society. This article summarizes qualitative and quantitative human and financial tolls from smoking. The tolls range from cigarette burns, to cigarette ignited fire disasters, to caring for dying smokers and replacing their financial and social contributions to their spouses, children, grandchildren, and the tax base. In the face of such costs, smoking cessation and prevention services are likely to be highly cost-effective.

Injury death excesses in smokers: a 1990-95 United States national cohort study.

OBJECTIVES: Assess injury death relative risks (RR), dose-response, and attributable fractions for current cigarette smokers (smokers) in a recent representative sample of the United States population without and with adjustment for (a) demographic and (b) additional behavioral risk factors. SETTING: United States. METHODS: National Health Interview Survey (NHIS) adult (ages 18+ years) interviewees from 1990 or 1991 were followed through 1995. Referents had never smoked a total of 100 cigarettes. Relative risks were estimated with Stata software's Cox proportional hazard regressions, using NHIS final weights and primary sampling units. The resulting RR and published data were used to estimate population smoking attributable fractions of injury deaths in the United States. RESULTS: The crude, age-race-gender adjusted, and fully (demographic plus educational attainment, marital status, alcohol use level, and seat belt use) adjusted RRs for injury death in smokers were 1.86 (95% confidence interval (CI) 1.30 to 2.66), 1.60 (CI 1.12 to 2.29), and 1.42 (CI 0.99 to 2.05) respectively. Those RRs correspond to United States injury death smoking attributable fractions of 18%, 13%, and 9%, respectively. Those smoker/ injury death RRs each showed a significant dose response relationship (p<0.030). Smokers' unadjusted unintentional injury, motor vehicle crash, and suicide RRs were 1.87 (CI 1.22 to 2.86), 2.14 (CI 1.12 to 4.11), and 2.17 (CI 1.02 to 4.62), respectively. CONCLUSIONS: Smokers in the United States have significant dose-response excesses of injury death, independent of age, race, gender, alcohol use, seat belt use, education, and marital status. This supports earlier studies suggesting that smoking may be a leading contributor to injuries and injury may be a leading burden from smoking, both nationally and globally.

Might stopping smoking reduce injury death risks? A meta-analysis of randomized, controlled trials.

BACKGROUND: Smokers have excesses of injuries. Randomized, controlled trials (RCT) could assess whether cigarette smoking (smoking) causes (and smoking cessation (cessation) prevents) those injuries. We analyzed injury, accident, suicide, and homicide deaths as secondary endpoints in RCT that induced cessation. METHODS: RCT were sought via MEDLINE, bibliographies, the CDC Smoking and Health database, and the GLOBALink Tobacco listserver. RCT were included if (1) net (intervention minus control) cessation totaled over 10% of all intervention smokers and (2) injury data were available. Relative risks (RR) were summarized by fixed effects modeling. RESULTS: Three trials were located (the Lung Health Study, MRFIT, and Whitehall RCT). In-trial annual point prevalence cessation averaged 41, 46, and 59% in the intervention group smokers versus 17, 22, and 28% in the respective controls. Intervention (cessation) was associated with pooled injury RR of 0.65 within the trials (95% confidence interval (CI) 0.36-1.19) and 0.68 (95% CI 0.43-1.09) with additional follow-up in the Lung Health and MRFIT populations. CONCLUSIONS: The smoking/injury death association is of borderline statistical significance in currently available RCT data. It modestly supports the significant forensic, cohort, case-control, cross-sectional, challenge-rechallenge, in vitro, and animal data suggesting that smoking may cause injury. Direct tests of the hypothesis could strengthen this inference.

Smoking as a risk factor for injury death: a meta-analysis of cohort studies.

BACKGROUND: Injury and tobacco effects represent one-quarter of the global burden of disease. Understanding the causes of injury and the effects of smoking may help reduce those burdens. Some smokers have high risks of injury. We provide an initial meta-analysis of cohort associations between smoking and fatal injury. METHODS: Three authors independently searched MEDLINE, and bibliographies of the pertinent studies found, for cigarette smoker-specific injury death data which allowed estimation of an appropriate relative risk (RR) and 95% confidence interval (CI). Relative risks and dose response were summarized by fixed effects and Poisson modeling, respectively. RESULTS: Six studies covering 10 pertinent cohorts were located. Associations between smoking and injury death have been significant after adjustment or, in effect, stratification for age, race, sex, country, and, respectively, alcohol, marriage, education, and body mass; job and time period; job, alcohol, and exercise; etc. Summary dose-response trends were significantly positive (P < 0.00005). Cigarette smoking predicted summary injury death crude RRs of 1.61 (CI 1.44-1.81) vs never smokers and 1.39 (CI 1.25-1.55) vs ex-smokers. CONCLUSIONS: Smoking has significant, consistent, dose-response, often strong and independent, prospective associations with injury death, internationally.

Wasted health care dollars. Routine cord blood type and Coombs' testing.

OBJECTIVE: To determine if selective newborn cord blood testing (NCBT) could contain costs without increasing morbidity of hemolytic disease of the newborn (HDN). DESIGN: A national telephone survey confirmed the common practice of routine blood type and Coombs' NCBT. Two 12-month study arms, retrospective and prospective, were conducted. Hemolytic disease of the newborn was studied retrospectively under an unrestricted NCBT policy. Then, HDN was studied after a policy change that restricted NCBT to patients in newborn intensive care units and normal newborns with clinical jaundice or Rh-negative mothers, and/or positive maternal antibody screenings, or unavailable maternal blood testing. PARTICIPANTS: All newborns (N = 8501) at the Metro-Health Medical Center, Cleveland, Ohio, were studied (retrospective arm, all 1989 admissions; prospective arm, all July 1990 to June 1991 admissions). OUTCOME MEASURES: Blood type and Coombs' NCBT, maternal blood type and antibody screening, Hobel risk scores for clinical severity of newborn hospitalization, duration of hospitalizations, and peak serum bilirubin levels. RESULTS: No quantitative or qualitative increases in morbidity from jaundice were detected by retrospective analysis with unrestricted NCBT, or prospectively after selective testing on 4498 newborns. Each study arm resulted in 15 readmissions for jaundice; these included two patients with ABO HDN. Furthermore, selective testing resulted in performance of NCBTs on only 390 infants in the "normal" nursery (24% of the original sample). Estimates projected on 1991 US births (4,111,000) showed that selective NCBT offers potential yearly savings above $30.8 million of patient charges, savings above $11.3 million of hospital costs, and the reassignment of more than 112 personnel full-time equivalents. CONCLUSION: Selective NCBT decreases the use of resources and costs without apparent additional patient morbidity from HDN.

Physician referrals for smoking cessation: outcome in those who show and don't show.

BACKGROUND: Only recently have clinical programs for smoking cessation become available in some medical centers. Counselor intervention services are provided to Mayo patients, most of whom are physician referred. Each patient receives a 45- to 60-min consultation and then is enrolled in a structured follow-up/relapse prevention program. METHODS: In 1989, 224 of 1764 patients referred by their physicians for consultation did not receive the consultation. This cohort was surveyed 1 year after referral to determine smoking status. We compared these patients to a cohort of 578 patients who were seen in 1988 for counseling and received the follow-up program. RESULTS: Of those referred, 87.3% received consultation. There was a 0.7%, 1-year point prevalence self-reported smoking cessation rate for those who were referred but did not follow through compared with 23.0% for those seen by the counselor and who received the follow-up program. CONCLUSIONS: In a medical setting, physician referral for nicotine dependence intervention and counselor-provided services is associated with a high attendance rate. Receiving counselor-provided consultation and follow-up was associated with a doubling of the stop rate. Such counselor services have substantial utility. There is a need for broader implementation of this type of service in medical centers.

Reducing risk of infection when obtaining hematocrit and bilirubin determinations: beyond universal precautions.

Obtaining hematocrit and bilirubin determinations is associated with infection risks, including human immunodeficiency virus infection. This study describes two simple procedures to decrease the risk of infection to health care providers while obtaining hematocrit and bilirubin determinations. Using readily available, inexpensive items (nonsterile gauze, a standard file, and plastic holder) and some simple techniques, the risk of infection can be decreased without increasing the time required. We believe these procedures are very reasonable and simple solutions to a common nursery problem.

Environmental tobacco smoke hazards and benefits of work-site nonsmoking programs.

The Council on Scientific Affairs of the California Medical Association presents the following inventory of items of progress in occupational medicine. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, and scholars to stay abreast of these items of progress in occupational medicine that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another. The items of progress listed below were selected by the Advisory Panel to the Section on Occupational Medicine of the California Medical Association, and the summaries were prepared under its direction.