Advances in the development of new vaccines for tuberculosis and Brazil's role in the effort forward the end TB strategy.

Tuberculosis (TB) continues to be the world's leading killer of infectious diseases. Despite global efforts to gradually reduce the number of annual deaths and the incidence of this disease, the coronavirus disease 19 (COVID-19) pandemic caused decreased in TB detection and affected the prompt treatment TB which led to a setback to the 2019 rates. However, the development and testing of new TB vaccines has not stopped and now presents the possibility of implanting in the next five years a new vaccine that is affordable and might be used in the various key vulnerable populations affected by TB. Then, this assay aimed to discuss the main vaccines developed against TB that shortly could be selected and used worldwide, and additionally, evidence the Brazilian potential candidates' vaccines in developing in Brazil that could be considered among those in level advanced to TB end.

Advances in the development of new vaccines for tuberculosis and Brazil’s role in the effort forward the end TB strategy

Tuberculosis (TB) continues to be the world’s leading killer of infectious diseases. Despite global efforts to gradually reduce the number of annual deaths and the incidence of this disease, the coronavirus disease 19 (COVID-19) pandemic caused decreased in TB detection and affected the prompt treatment TB which led to a setback to the 2019 rates. However, the development and testing of new TB vaccines has not stopped and now presents the possibility of implanting in the next five years a new vaccine that is affordable and might be used in the various key vulnerable populations affected by TB. Then, this assay aimed to discuss the main vaccines developed against TB that shortly could be selected and used worldwide, and additionally, evidence the Brazilian potential candidates’ vaccines in developing in Brazil that could be considered among those in level advanced to TB end.

Advances in the development of new vaccines for tuberculosis and Brazil's role in the effort forward the end TB strategy

Tuberculosis (TB) continues to be the world's leading killer of infectious diseases. Despite global efforts to gradually reduce the number of annual deaths and the incidence of this disease, the coronavirus disease 19 (COVID-19) pandemic caused decreased in TB detection and affected the prompt treatment TB which led to a setback to the 2019 rates. However, the development and testing of new TB vaccines has not stopped and now presents the possibility of implanting in the next five years a new vaccine that is affordable and might be used in the various key vulnerable populations affected by TB. Then, this assay aimed to discuss the main vaccines developed against TB that shortly could be selected and used worldwide, and additionally, evidence the Brazilian potential candidates' vaccines in developing in Brazil that could be considered among those in level advanced to TB end.

Avaliação de proteínas secretadas e de superfície de Schistosoma Mansoni como antígenos vacinais usando um sistema apresentador de múltiplos antígenos ( MAPS-OMV)

As principais vacinas comercializadas atualmente seguem a estratégia da vacinologia convencional, baseada nos Princípios de Pasteur: “Isolar, inativar e injetar” o microrganismo causador da doença. Porém essa abordagem não se à patógenos com grande variabilidade antigênica ou organismos mais complexos, os quais possuem mecanismos de evasão do sistema imune mais sofisticados. Novas abordagens e tecnologias incluem o uso de rotas alternativas de imunização e novos adjuvantes. A esquistossomose é considerada a mais importante das helmintíases humanas em termos de morbidade e mortalidade. Um possível racional para o desenvolvimento de uma vacina anti-helmíntica seria selecionar moléculas secretadas ou expostas na superfície como candidatos vacinais, com o objetivo de interferir com a migração / desenvolvimento do parasita, bloqueando ou prejudicando processos-chave, tais como a penetração na pele, a penetração dos vasos sanguíneos e a alimentação.e membrana externa (OMVs) na mesma construção...