1.
Synthesis of intrathecal interferon in systemic lupus erythematosus with neurological complications.
Br Med J (Clin Res Ed)
; 287(6400): 1165-7, 1983 Oct 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6414612
RESUMO
Intrathecal synthesis of interferon in the absence of viral or bacterial infection was detected during the occurrence of neurological complications in two patients with systemic lupus erythematosus. The interferons displayed characteristics similar to those observed in the sera of patients with the disease. No interferon inducing activity was detected in the cerebrospinal fluid or serum of the two patients. These observations support the hypothesis of a localised mechanism of interferon induction in systemic lupus erythematosus which includes the interaction of lymphocytes with damaged tissues.
Assuntos
Doenças do Sistema Nervoso Central/líquido cefalorraquidiano , Interferon Tipo I/biossíntese , Lúpus Eritematoso Sistêmico/líquido cefalorraquidiano , Adolescente , Doenças do Sistema Nervoso Central/etiologia , Criança , Feminino , Humanos , Interferon Tipo I/sangue , Interferon Tipo I/líquido cefalorraquidiano , Lúpus Eritematoso Sistêmico/complicações
2.
J Pediatr
; 98(3): 503-4, 1981 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6782217