[An experience with neuroprotective therapy of primary open-angle glaucoma based on the use of different dosage forms of Mexidol]. / Opyt neiroprotektornoi terapii pervichnoi otkrytougol'noi glaukomy na osnove primeneniya razlichnykh form Meksidola.

UNLABELLED: Aim - to develop an algorithm to guide neuroprotective therapy in railway workers undergoing long-term follow-up for primary open-angle glaucoma (POAG) judging from the efficacy of sequential administration of intravenous dosage form of Mexidol and oral tablets. MATERIAL AND METHODS: All sorts of JSC Russian Railways employees with stage I-III POAG and well-controlled intraocular pressure were enrolled. Mexidol was first to be administered intravenously by a dropper in a day hospital (250 mg daily for 5 days) and then taken orally at home (125 mg t.i.d. for 3 months). A comprehensive ophthalmic examination with high-technology control was performed in all patients at their first, second, and third follow-up visits. RESULTS: Data from 58 patients (96 eyes) were analyzed. Statistically significant improvements in perimetry and optical coherence tomography results were only obtained at a third visit, i.e. at the end of the course of Mexidol tablets. The treatment effect was most pronounced in stage I-II patients. CONCLUSION: The results suggest that combination therapy with intravenous and oral Mexidol received sequentially as well as long-term (3-month) administration of Mexidol tablets can both be recommended in POAG patients. It has been also found that neuroprotective therapy with Mexidol performs best for early stages of the disease.

[Results of deep clinical and physiologic study of eye in locomotive operators].

Eye functioning in locomotive operators remains at high level for a long time, in spite of exposure to complex of occupational hazards, but without correction of early visual disorders some diseases might involve accomodation, refraction and neurosensory divisions of eye, with subsequently more difficult operator's work at railway and the railway traffic safety hazard.

[Morphologic characteristics of secondary tubulointerstitial nephritis in humans and in rabbit experiments]. / Morfologicheskaia kharakteristika vtorichnogo tubulointerstitsial'nogo nefrita u cheloveka i v éksperimente u krolikov.

Tubulo-stromal relationships were studied in rabbit and human kidneys in secondary tubulo-interstitial nephritis (TIN) of immune genesis to establish the species differences in the course and manifestations of this disease. TIN of rabbits was studied on the model of serum disease (13 animals) and in humans on renal biopsies from patients with mesangioproliferative GN (22 cases). The correlation of relative volumes of tubule structural elements characteristic for each species undergoes changes when pathologic process develops; new correlations are similar in both humans and rabbits, although the time of involvement of tubular part of nephron into the pathologic process is different. Immunohistochemically and electron-microscopically a diffuse character of the damage is shown.

[A method of determining the kinetics of activation of the complement system]. / Metod opredeleniia kinetiki aktivatsii sistemy komplementa.

A method for studies of the kinetics of the routine and alternative complement system activation has been developed, consisting in regular scintillation of the red cell count in the test system with the use of the Pikoskel laboratory cell scintillator. A relationship between the rate of the red cell count reduction and the complement system compensatory activity in the examined patients has been demonstrated.

[Dynamics of inherent interactions between the classical and alternative pathways of complement activation in premature infants with suppurative-inflammatory diseases]. / Dinamika vnutrennego vzaimodeistviia mezhdu klassicheskim i al'ternativnym putiami aktivatsii sistemy komplementa u nedonoshennykh novorozhdennykh pri gnoino-vospalitel'nykh zabolevaniiakh.

Altogether 57 premature infants were examined. Of these, 15 presented with neonatal sepsis, 36 with local purulent infection (LPI) of different etiology, and 6 children were conventionally normal serving as control. Early activation of the alternative pathway of the complement system was shown by the patients as compared with control. The development of neonatal sepsis was attended by the increased role played by the classical pathway of complement activation. At the same time the course of LPI was characterized by differences in the degree of participation of the classical and alternative pathways in the antiinfectious defence of the neonates. It has been established that high activation of the alternative pathway seen in the premature children may be considered as a prognostic sign enabling one to classify them with the risk group in terms of the possibility of the development in them of an infectious process.

[Effect of an alphavirus infection in pregnant mice on the susceptibility of their progeny to homologous infection in the postnatal period]. / Vliianie al'favirusnoi infektsii beremennykh myshei na vospriimchivost' potomstva k gomologichnoi infektsii v postnatal'nom periode.

Infection of random-bred mice with Sindbis virus at various intervals of pregnancy results in increased resistance of their offsprings to infection with this virus in the first days after birth. Antibodies present in the colostrum and milk of immunized females play an important role in decreasing the susceptibility of sucklings to alphavirus infection.

[Characteristics of experimental alphavirus infection during pregnancy and in the early stages of ontogeny in mice]. / Osobennosti éksperimental'noi al'favirusnoi infektsii vo vremia beremennosti i na rannikh éatapkh ontogeneza u myshei.

Inoculation of random-bred mice with Sindbis virus at various periods of pregnancy resulted in the development of marked changes and loss of 24.7% of fetuses when mice were infected at the stage of placentation. Retardation in the development and death of progeny in females infected at later stages of pregnancy were observed. Antibody production was shown to be enhanced in pregnant mice as compared with non-pregnant. Possible mechanisms of increased susceptibility to alphaviruses during pregnancy and in early stages of ontogenesis are discussed. A potential danger of development of embryo- and fetopathies in humans is considered on the basis of the above studies and the data on equivalent stages of prenatal development of mice and human beings.