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Colloids Surf B Biointerfaces ; 111: 741-6, 2013 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-23916964

RESUMO

The relationship between electrical conductivity, structure and antibacterial properties of chitosan-silver nanoparticles (CS/AgnP) biocomposites has been analyzed. To test the film's antimicrobial activity, Gram-positive and Gram-negative bacteria were studied. The interactions between silver nanoparticles with chitosan suggest the formation of silver ions which plays a major role in nanocomposite's bactericidal potency. In CS/AgnP biocomposites, the bactericide effectiveness increases by increasing AgnP concentrations up to 3 wt%, which is close to the electrical percolation threshold of ca. 3 wt%. As the AgnP concentration increases above this threshold, the bactericidal potency is greatly diminished. The elucidated correlation between electrical conductivity and antibacterial activity could be useful in the design of other nanocomposites that involve polymeric-based matrices.


Assuntos
Antibacterianos/farmacologia , Quitosana/farmacologia , Condutividade Elétrica , Prata/farmacologia , Bactérias/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Nanocompostos/ultraestrutura , Espectroscopia Fotoeletrônica , Espectroscopia de Infravermelho com Transformada de Fourier
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