Assuntos
Doxorrubicina/farmacologia , Hemostasia/fisiologia , Animais , Divisão Celular/efeitos dos fármacos , Dipiridamol/farmacologia , Doxorrubicina/uso terapêutico , Glutamatos/farmacologia , Heparina/farmacologia , Neoplasias Pulmonares/sangue , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/patologia , Camundongos , Camundongos Endogâmicos C57BL , Metástase NeoplásicaRESUMO
Acute toxicity and radioprotective properties of 16 derivatives of tetrahydro- and dihydropyrimidines were studied in experiments on mice. Hydroiodides of 4,6,6-trimethyl-3,R-2-methylthio-3,6-dihydropyrimidines were shown to be more toxic than respective hydroiodides of 4,6,6-trimethyl-3-R-2-methylthio-4-oxy-3,4,5,6-tetrahydropyrimidines. Four compounds exhibited moderate radioprotective properties.
Assuntos
Pirimidinas/toxicidade , Protetores contra Radiação , Animais , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Feminino , Raios gama , Dose Letal Mediana , Camundongos , Doses de Radiação , Relação Estrutura-Atividade , Fatores de TempoRESUMO
Toxicity and radioprotective properties of 18 derivatives of oxazine and thiazine with a varying degree of the cycle saturation were studied in experiments on mice. Monotypic regularity in variations of their toxic properties relative to the chemical structure was noted. 4,4,6-Trimethyl-2-dimethylamino-4H-1,3-oxazine exerted a pronounced radioprotective action.
Assuntos
Oxazinas/toxicidade , Protetores contra Radiação , Tiazinas/toxicidade , Animais , Raios gama , Injeções Intraperitoneais , Dose Letal Mediana , Masculino , Camundongos , Relação Estrutura-AtividadeRESUMO
Toxicity, radioprotective and antiinflammatory properties of 20 vinyl derivatives of quinoline and products of their transformations were studied in experiments on Wistar mice and rats. The salts of quinoline vinyl derivatives (compounds VI, IX, XII, and XVIII) were shown to be more toxic than respective initial compounds (VI, VIII, XI and XVI). 8-(beta-Butylthio)-ethyloxyquinoline (compound IV) protected 25% of irradiated mice from death. Compounds I, XII, XVI and XVIII exerted a radioprotective action (in 10-15%), whereas the remaining substances proved ineffective. The combination of 8-vinyloxyquinoline and iodine (compound IV) elicited a marked antiinflammatory action in experimental serotonin-, dextran- and to a less measure formalin-induced inflammation.
Assuntos
Quinolinas/farmacologia , Compostos de Vinila/farmacologia , Animais , Anti-Inflamatórios , Feminino , Dose Letal Mediana , Camundongos , Quinolinas/toxicidade , Protetores contra Radiação , Compostos de Vinila/toxicidadeRESUMO
In experiments set up on mice, rats and guinea pigs 8 gamma-pyron derivatives were studied. They proved to be little toxic, do not change significantly the arterial pressure and respiration, exercise a depressing action on the central nervous system, produce a marked antiphlogistic (normal and irradiated animals), radio-protective and antihistaminic effects and influence norephinephrine, homovanillic acid and dopamine metabolism in the brain.