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1.
Clin Biomech (Bristol, Avon) ; 63: 140-146, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30889433

RESUMO

BACKGROUND: Falls are one of the main concerns in people with Parkinson's disease, leading to poor quality of life and increased mortality. The sit-to-walk movement is the most frequent postural transition task during daily life and is highly demanding in terms of balance maintenance and muscular strength. METHODS: With the aim of identifying biomechanical variables of high risk of falling, we investigated the sit-to-walk task performed by 9 Parkinson's disease patients with at least one fall episode in the six months preceding this study, 15 Parkinson's disease patients without previous falls, and 20 healthy controls. Motor performance was evaluated with an optoelectronic system and two dynamometric force plates after overnight suspension of all dopaminergic drugs and one hour after consumption of a standard dose of levodopa/benserazide. FINDINGS: Poor trunk movements critically influenced the execution of the sit-to-walk movement in patients with a history of falling. The peak velocity of the trunk in the anterior-posterior direction discriminated faller from non-faller patients, with high specificity and sensitivity in both the medication-off and -on state. INTERPRETATION: Our results confirm the difficulties in merging consecutive motor tasks in patients with Parkinson's disease. Trunk movements during the sit-to-walk can provide valuable measurements to monitor and possibly predict the risk of falling.


Assuntos
Acidentes por Quedas/prevenção & controle , Doença de Parkinson/fisiopatologia , Equilíbrio Postural , Postura Sentada , Caminhada , Idoso , Idoso de 80 Anos ou mais , Benserazida/administração & dosagem , Estudos de Casos e Controles , Combinação de Medicamentos , Feminino , Humanos , Levodopa/administração & dosagem , Masculino , Pessoa de Meia-Idade , Movimento , Qualidade de Vida , Sensibilidade e Especificidade
2.
PLoS One ; 13(6): e0198691, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29874298

RESUMO

The role of the subthalamic nucleus in human locomotion is unclear although relevant, given the troublesome management of gait disturbances with subthalamic deep brain stimulation in patients with Parkinson's disease. We investigated the subthalamic activity and inter-hemispheric connectivity during walking in eight freely-moving subjects with Parkinson's disease and bilateral deep brain stimulation. In particular, we compared the subthalamic power spectral densities and coherence, amplitude cross-correlation and phase locking value between resting state, upright standing, and steady forward walking. We observed a phase locking value drop in the ß-frequency band (≈13-35Hz) during walking with respect to resting and standing. This modulation was not accompanied by specific changes in subthalamic power spectral densities, which was not related to gait phases or to striatal dopamine loss measured with [123I]N-ω-fluoropropyl-2ß-carbomethoxy-3ß-(4-iodophenyl)nortropane and single-photon computed tomography. We speculate that the subthalamic inter-hemispheric desynchronization in the ß-frequency band reflects the information processing of each body side separately, which may support linear walking. This study also suggests that in some cases (i.e. gait) the brain signal, which could allow feedback-controlled stimulation, might derive from network activity.


Assuntos
Estimulação Encefálica Profunda , Marcha/fisiologia , Rede Nervosa/fisiologia , Doença de Parkinson/terapia , Núcleo Subtalâmico/fisiologia , Idoso , Retroalimentação Fisiológica , Feminino , Análise da Marcha/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Neurônios/fisiologia , Doença de Parkinson/diagnóstico por imagem , Doença de Parkinson/fisiopatologia , Posição Ortostática , Núcleo Subtalâmico/citologia , Núcleo Subtalâmico/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Estimulação Elétrica Nervosa Transcutânea
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