Assuntos
Adenocarcinoma/tratamento farmacológico , Neoplasias do Colo/tratamento farmacológico , Fluoruracila/administração & dosagem , Neoplasias Retais/tratamento farmacológico , Tetra-Hidrofolatos/administração & dosagem , Adenocarcinoma/mortalidade , Adulto , Idoso , Ensaios Clínicos como Assunto , Neoplasias do Colo/mortalidade , Quimioterapia Combinada , Feminino , Fluoruracila/efeitos adversos , Humanos , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Neoplasias Pélvicas/tratamento farmacológico , Neoplasias Pélvicas/secundário , Neoplasias Retais/mortalidade , Tetra-Hidrofolatos/efeitos adversosRESUMO
Bone marrow examination is commonly included in the staging of small cell lung carcinoma (SCLC). We reviewed marrow samples of 103 patients. Marrow examination was mainly performed by unilateral or bilateral biopsy of iliac crests, using a Jamshidi needle. Only 6 of 97 evaluable cases (6.2 per cent) were positive for marrow metastases at staging, and in 3 cases (3 per cent) bone marrow was the only metastatic site. No focal metastases were found in additional sections made from the blocks of negative samples. In our experience bone marrow biopsy was of little value in staging SCLC. Bilateral biopsy plus aspirate, with the addition of more sophisticated staining techniques might, however, provide a higher yield of positive marrow involvement.
Assuntos
Exame de Medula Óssea , Carcinoma de Células Pequenas/patologia , Neoplasias Pulmonares/patologia , Adulto , Idoso , Biópsia , Medula Óssea/patologia , Osso e Ossos/patologia , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de NeoplasiasRESUMO
One hundred sixty-five patients with surgically treated thymoma were followed over 28 years; 73% had myasthenia gravis at presentation. Invasiveness was based on macroscopic findings at operation. Postsurgical radiotherapy or chemotherapy were not routinely used. Overall survival was 84%, 79%, and 65% at 3, 5, and 10 years, respectively. Patients with invasive thymoma survived for a shorter period than patients with noninvasive tumors (67% versus 85% at 5 years); when radical excision was possible, no difference was detectable between the two groups. Patients with subtotally resected or only biopsied invasive thymomas survived 59% and 42% at 5 years, respectively. Lymphoepithelial cases had the worst prognosis of the histologic types considered. Myasthenia gravis did not adversely affect survival. Surgery is the basic treatment of thymomas. Macroscopic invasiveness and degree of excision judged by the surgeon have prognostic value and are reliable criteria of malignancy. Radiotherapy and chemotherapy may be effective, but their use should be limited to controlled trials.
Assuntos
Timoma/cirurgia , Neoplasias do Timo/cirurgia , Adolescente , Adulto , Fatores Etários , Idoso , Feminino , Seguimentos , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/patologia , Metástase Neoplásica , Recidiva Local de Neoplasia/epidemiologia , Estadiamento de Neoplasias , Cuidados Pós-Operatórios , Fatores Sexuais , Timectomia , Timoma/mortalidade , Timoma/patologia , Timo/patologia , Neoplasias do Timo/mortalidade , Neoplasias do Timo/patologiaRESUMO
Hepatocellular carcinoma has a poor prognosis and is poorly responsive to systemic chemotherapy. Here we describe a case with unresectable hepatocellular carcinoma who achieved a complete response and has survived for more than 2 years, following treatment with a combination of adriamycin and etoposide (VP 16-213).
