Assuntos
Proteínas de Fusão bcr-abl/biossíntese , Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico , Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo , Transtornos Mieloproliferativos/diagnóstico , Transtornos Mieloproliferativos/metabolismo , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo , Adulto , Sequência de Bases , Criança , Progressão da Doença , Seguimentos , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/genética , Dados de Sequência Molecular , Transtornos Mieloproliferativos/genética , Reação em Cadeia da Polimerase , Leucemia-Linfoma Linfoblástico de Células Precursoras/genética , RNA Mensageiro/genética , RNA Mensageiro/metabolismoRESUMO
Antiperinuclear factors (APF) are directed to epithelial cell "kerato-hyaline granules". Standardization of the APF test has been achieved, but the way to express the results is still debatable. APF were found to be present in 76% of rheumatoid arthritis (RA) patients: thus the sensitivity and the specificity for RA were 76 and 97%, respectively. No clinical or serological associations were substantiated in RA. The antigens targetted by these auto-antibodies are extremely variable from one to another donor.
Assuntos
Anticorpos Antinucleares/análise , Artrite Reumatoide/imunologia , Anticorpos Antinucleares/isolamento & purificação , Variação Antigênica , Imunofluorescência , HumanosRESUMO
Lymphocytes from 12 rheumatoid arthritis patients were phenotyped before and after a 2-month treatment with tiopronin. Originally reduced, CD4 CD45RA-T lymphocytes were shown to augment significantly. Abnormal activation (evaluated on HLA-DR and CD25 expression) of each cell population and sub-population was partially amended.
Assuntos
Artrite Reumatoide/sangue , Linfócitos T CD4-Positivos/efeitos dos fármacos , Subpopulações de Linfócitos T/efeitos dos fármacos , Tiopronina/farmacologia , Adulto , Idoso , Artrite Reumatoide/tratamento farmacológico , Artrite Reumatoide/imunologia , Antígenos CD4/análise , Linfócitos T CD4-Positivos/imunologia , Antígenos CD8/análise , Feminino , Humanos , Antígenos Comuns de Leucócito/análise , Masculino , Pessoa de Meia-Idade , Subpopulações de Linfócitos T/imunologiaRESUMO
We investigated the endocrine response to an experimental protocol in which human menopausal gonadotropin was delivered in pulses every 90-120 minutes by an automated pump. Thirty clomiphene citrate- and gonadotropin-releasing hormone-unresponsive anovulatory women were studied over 107 treatment cycles. In response to episodic intravenous (IV) delivery, pulses of FSH and LH were demonstrable in the circulation. In four World Health Organization (WHO) group I anovulatory women, ovulation occurred in all cycles (N = 8); the pregnancy rate per cycle was 63% and the cumulative pregnancy rate 100%. In 26 WHO group II patients, 42.4% of treatment cycles were in 12 women previously refractory to the intramuscular route of administration; the rate for ovulation was 86% (total of 99 cycles), the pregnancy rate per ovulatory cycle was 14%, and the cumulative pregnancy rate 56%. A mild phlebitis occurred at the site of the IV catheter in 24% of treatment cycles. Intravenous delivery of gonadotropins in small pulses had a dose-sparing effect and was an effective method of treating anovulatory infertile patients refractory to other conventional methods of ovulation induction.
