RESUMO
Fifty eight patients with rhino-conjunctivitis caused by grass pollen were included in a double-blind study in which they received, by the sub-lingual route over 5 months, either a solution of purified and standardised allergen or a placebo. Assessment of the effect of this immunotherapy, which was done with drops of Stallergenes "5-grass pollen" was by clinical symptoms and the use of authorized drugs and treatments. Compared with the placebo group, the patients on active treatment showed significantly less (P = 0.05 to P = 0.01) rhinitis symptoms (sneezing and rhinorrhea) and conjunctivitis (reddening and tears) during the pollen season. Consumption of nasal cromoglycate solution, of betamethasone and dexchlorpheniramine was significantly lower (p = 0.01) in the desensitised group. Secondary effects were negligible. From this study, it can be concluded that immunotherapy with grass pollen extract, by the sub-lingual route, of patients with rhino-conjunctivitis who were sensitive to these allergens, is efficacious, easy to do, economic and sure.
Assuntos
Alérgenos/administração & dosagem , Conjuntivite Alérgica/terapia , Dessensibilização Imunológica , Pólen/imunologia , Rinite Alérgica Sazonal/terapia , Administração Sublingual , Adolescente , Adulto , Alérgenos/efeitos adversos , Alérgenos/imunologia , Alérgenos/uso terapêutico , Betametasona/uso terapêutico , Clorfeniramina/uso terapêutico , Terapia Combinada , Conjuntivite Alérgica/tratamento farmacológico , Cromolina Sódica/uso terapêutico , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Poaceae , Rinite Alérgica Sazonal/tratamento farmacológico , Terfenadina/uso terapêutico , Resultado do TratamentoRESUMO
Allergy to latex causes serious accidents that are often unrecognised. These accidents are perfectly predictable by a simple interrogation, together with skin and biological tests. Populations at risk can be identified: persons undergoing treatment, particularly the disabled and also housewives. There is a risk of further increases in the number of cases of hypersensitivity to latex due to the expanding use of preservatives. The study undertaken at the CHU at Angers has shown that allergy to fruits is frequent in patients who are sensitive to latex. The exact nature of allergy to Hevea is not yet well understood: it is not possible at present to decide whether there is "crossed allergy" or whether it is one part of a larger syndrome.
