[Rationale of noninvasive method of drug administration at the prelymphatic level]. / Obosnovanie neinvazivnogo metoda vvedeniia lekarstvennykh veshchestv na urovne prelimfaticheskogo zvena.

The paper deals with the mode of local drug administration into the biological tissue at the prelympathic level without damaging the skin, which is based on enhancement of skin permeability by exposing to physical factors, including the use of contrast temperatures in the cyclic process of heating-cooling, followed by exposure to contact low-frequency ultrasound. Experimental and clinical studies of the mode versus routine drug administration have shown it to be promising in physiotherapeutic use.

[Modulation of the circadian rhythm of the glucocorticoid hormone level in mice by thymoptin administration at various times of day]. / Moduliatsiia sutochnogo ritma soderzhaniia gliukokortikoidnykh gormonob u myshei vvedeniem timoptina v raznoe vremia sutok.

A study was made of the level of corticosterone in mouse blood plasma after 4-time daily administration of thymopthin (a drug containing 1% of thymosin-alpha 1, synthesized in the All-Union Research Institute of Technology of Blood Substitution and Hormonal Drugs) at a doze of 0.05 mg per mouse in the morning and evening. The object of investigation was blood plasma of CBA male mice aged 12-16 weeks. The investigation was experimental. The purpose was to elucidate a possible role of thymic hormones in the regulation of circadian rhythm of glucocorticoid function of the adrenal cortex. Plasma concentration of corticosterone was determined by concurrent protein binding of hormones. Thymopthin administration was shown to result in change of circadian rhythm of the level of corticosteroids in mouse plasma. Drug administration in the morning elevated daily concentration of corticosterone, that also evening reduced it as compared to the control group that in the received the same volume of physiological salt solution. A curve of the daily time course was obtained as a result of smoothing by a method of the least squares. These results should be taken into account when using thymic drugs for therapeutic and experimental purposes.

[Diurnal dynamics of spatial-temporal organization of lymph nodes]. / Sutochnaia dinamika prostranstvenno-vremennoi organizatsii limfaticheskikh uzlov.

Experiments, performed on CBA mice demonstrate that all the parameters of lymph nodes of various localization possess a diurnal rhythmicity. Certain lympho-endocrine connections participate in realization of the regional peculiarities of the diurnal rhythms via regulation of redistribution of streams of the migrating lymphoid cells, that form the lymph node structures. There are certain differences in endogenous glucocorticoids action, depending on the level of the motor activity, that determines level of the mast cells activation, value of lymph-formation and blood stream intensity in the drained region. Concrete examples of the diurnal spatial-time organization of functional steps are described in inguinal, mesenteric and bifurcational lymph nodes.