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1.
Vaccine ; 42(9): 2135-2137, 2024 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-38453618

RESUMO

The COVID-19 pandemic has affected people of all ages worldwide. However, there is still no information on the vaccine effectiveness (VE) of inactivated COVID-19 vaccines in children aged less than 3 years old. This study highlighted that 2 doses of CoronaVac were effective in preventing COVID-19, with a VE of 83.1 %.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Vacinas de Produtos Inativados , Criança , Humanos , Pré-Escolar , COVID-19/prevenção & controle , Hong Kong/epidemiologia , Pandemias
2.
J Hazard Mater ; 87(1-3): 213-23, 2001 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-11566411

RESUMO

Chemical analysis of spent Co/Mo/gamma Al(2)O(3) catalyst revealed the presence of carbon, molybdenum, sulfur, vanadium and cobalt at levels of 16.0, 10.9, 7.3, 4.6 and 4.0 wt.%, respectively. It was found that calcination at 500 degrees C provides an effective solution for the removal of carbon and sulfur and this generates the oxide form of the heavy metals. The removal of these heavy metals can be achieved through a two-stage leaching process. During the first stage, in which concentrated ammonia is used and it has been found that this process can be successful in removing as much as 83% (w/v) Mo. In a second stage, it was found that using 10% (v/v) of sulfuric acid, it was possible to account for up to 77% (w/v) Co and 4% (w/v) Mo removal. Leaching test results indicated that the vanadium present in the heated spent catalyst was almost stabilized but the molybdenum and cobalt were not. The combination of two solid wastes, ladle furnace slag (LFS) and treated residue of spent catalyst, could be used for making a high value-added anorthite glass-ceramic materials. Further leaching tests showed that ceramic glass materials provided a very effective method of Co, Mo and V heavy metals stabilization resulting in a product with a possible commercial value.


Assuntos
Poluição Ambiental/prevenção & controle , Metais Pesados/análise , Silicatos de Alumínio/química , Catálise , Cerâmica/química , Vidro/química , Metais Pesados/química , Petróleo , Eliminação de Resíduos/métodos
3.
Biochem Biophys Res Commun ; 268(1): 133-5, 2000 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-10652226

RESUMO

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation.


Assuntos
Peptídeos beta-Amiloides/biossíntese , Ácido Aspártico Endopeptidases/antagonistas & inibidores , Ácido Aspártico Endopeptidases/metabolismo , Aldeídos/química , Aldeídos/farmacologia , Secretases da Proteína Precursora do Amiloide , Peptídeos beta-Amiloides/química , Animais , Sítios de Ligação , Células COS , Linhagem Celular , Desenho de Fármacos , Endopeptidases , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Humanos , Oligopeptídeos/química , Oligopeptídeos/farmacologia , Processamento de Proteína Pós-Traducional/efeitos dos fármacos , Relação Estrutura-Atividade
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