1.
Org Biomol Chem
; 12(8): 1245-9, 2014 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24414044
RESUMO
An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic frameworks.
2.
Org Lett
; 2(15): 2185-7, 2000 Jul 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10930239
RESUMO
Highly diastereoselective protonation of chiral lactam enolates of 4-substituted-1,4-dihydroisoquinolin-3-ones is reported. Protonation and alkylation processes of these lactam enolates derived from phenylglycinol occur with opposite diastereofacial selectivity. This diastereoselective protonation has been applied to the asymmetric synthesis of (4S)-N-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline 9 obtained in up to 97% ee.