[Factors for individualization of treating postoperative wound complications in stomach cancer patients]. / Faktory individualizatsii lecheniia posleoperatsionnykh ranevykh oslozhnenii u bol'nykh rakom zheludka.

Since gram-negative aerobic and anaerobic microorganisms constitute at present the largest fraction of microflora in surgical patients, the chances of their translocation from the intestines due to impaired anticolonization resistance of the body are becoming stronger. Evidence is presented to demonstrate the dynamics of postoperative infestation of wounds in patients operated on for stomach cancer.

[Comparative antibiotic susceptibility in vitro of microbial isolates from patients with complications after gastrectomy for stomach carcinoma and from contents of their large intestine]. / Sravnitel'naia chuvstvitel'nost' k antibiotikam in vitro mikroorganizmov, vydelennykh u bol'nykh rakom zheludka pri oslozhneniiakh posle gastréktomii i iz soderzhimogo tolstogo kishechnika.

Antibiotic susceptibility of the main isolates from the large intestine contents and pathological substrates of 12 patients after gastroectomy for stomach carcinoma was studied. Three of them developed esophagoenterostomy incompetence, 4 had intraabdominal abscesses and in 5 infection of the operation wound was stated. In all, 30 isolates of enterobacteria, 28 isolates of enterococci and 38 isolates of bacteroides were tested. Antibiotic susceptibility of the isolates from various sources was practically identical, which showed that before surgical operations for stomach carcinoma it was necessary that data on the patients intestine microbiocenosis and antibioticograms of the main isolates should be available to correct severe dysbiotic disorders.

[Non-sporulating anaerobic bacteria and anastomosis failure in patients with gastric carcinoma]. / Nesporoobrazuiushchie anaéroby pri razvitii nesostoiatel'nosti anastomozov u bol'nykh rakom zheludka.

Cases of anastomosis suture failure within the period from 1977 to 1987 and from 1988 to 1998 in 139 patients after various surgical operations for gastric carcinoma were analyzed. Infection in the cases of the anastomosis sUture failure at the early terms was mainly due to representatives of Enterobacteriaceae and at the later terms the failure was mainly due to non-sporulating anaerobes belonging to Bacteroidaceae. The data are indicative of the fact that the use of antimicrobials requires a differential approach.

[The efficacy of different antimicrobial preparations in treating patients with disseminated peritonitis]. / Izuchenie éffektivnosti razlichnykh antimikrobnykh preparatov pri lechenii bol'nykh s rasprostranennym peritonitom.

The results of our investigations revealed that in 68% of cases the treatment of patients with diffuse peritonitis with ampiox, gentamicin and metronidazole led to arresting the infectious process and to a considerable decrease in microbial contamination of the abdominal cavity. The use of cephalosporins and metronidazole proved to be effective in 85% of cases. In this treatment a considerable decrease in the amount of aerobic and anaerobic bacteria in peritoneal exudate was registered. In the process of treatment with cyprophloxacin positive clinical and microbiological dynamics were observed in all patients.

[The microflora of the peritoneal exudate in patients with disseminated peritonitis]. / Izuchenie mikroflory peritoneal'nogo ékssudata u bol'nykh s rasprostranennym peritonitom.

In 11 patients with diffuse peritonitis and 39 patients with general peritonitis the microflora of peritoneal exudate and the sensitivity of isolated microorganisms to antimicrobial preparations were studied. The study revealed that in the total number of microorganisms isolated from peritoneal exudate enterobacteria prevailed in patients with diffuse peritonitis and bacteroids, in patients with general peritonitis. Enterobacteria were most sensitive to ciprofloxacin and claforan, while bacteroids, to ciprofloxacin; at the same time 15.4% of the bacteroid strains under study were resistant to ciprofloxacin.

[The effect of different antimicrobial preparations on the normalization of the intestinal microflora in patients with disseminated peritonitis]. / Vliianie razlichnykh antimikrobnykh preparatov na normalizatsiiu mikroflory kishechnika u bol'nykh s rasprostranennym peritonitom.

These investigations revealed that the treatment of patients with generalized peritonitis with ampiox, gentamicin and metronidazole, as well as with cephalosporins and metronidazole, led to the aggravation of dysbiotic disturbances in normal intestinal microflora, observed in these patients before treatment. Ciprofloxacin had a selective decontaminating effect on the intestine, which facilitated the decrease of suppuration in postoperative wounds.

[Ciprofloxacin and other antimicrobial drugs in the treatment of disseminated peritonitis]. / Primenenie tsiprofloksatsina i drugikh antimikrobnykh preparatov pri lechenii rasprostranennogo peritonita.

Forty two patients with general peritonitis were treated with ciprofloxacin and combinations of various antimicrobial drugs. Ciprofloxacin had the highest effect on aerobic and anaerobic microbes in the peritoneal cavity which defined the favourable clinical results in all the patients. Moreover, there were observed no disorders in the composition of the normal intestinal microflora which in the end promoted a decrease in the number of the patients with suppuration of the surgical wound.