Organ distribution and autoradiography after administration of 125I-16 alpha-iodo-estradiol in female rats.

Tissue distribution experiments with 125I-1 16 alpha-iodo-estradiol (Amersham) showed the highest tissue-to-blood ratio of 3 to 8 in the liver, uterus, mammary gland, ovaries and adrenals up to 2 h after the injection. Satisfactory images with a simple autoradiographical techniques according to Stumpf [1971] have been achieved at 2 h after the injection of drug.

Developmental trends of liver parenchyma in the terminal period of gestation: a stereological approach.

The aim of the presented study was to establish the baseline data concerning the volumes density of basic architectonic components of human fetal liver parenchyma. The stereological measuring principles of the point-counting method were used. The livers of 38 appropriate for gestational age fetuses, and 12 small for gestational age fetuses were measured. All fetuses investigated were stillborns. A lower volume density of hepatocytic population was found in full-term mature fetuses, when compared with the adults. A lower volume density of hepatocytes has been also disclosed in intra-uterine growth retarded fetuses, when compared with their physiologically developed counterparts of the same gestational age.

[Tolbutamide as a stimulator of somatotropin secretion from the hypophysis]. / Tolbutamid als Stimulator der Ausschüttung des Wachstumshormons aus der Hyopohyse.

Our clinical experiments should point at the potential quality of tolbutamide as a stimulator of the secretion of the growth hormone. This could not be ascribed to the hypoglycaemic action of tolbutamide, because during the 240 minutes' time of the duration of the test, the glycaemic levels in the blood have been kept stabilised at the same levels as in fasting conditions before the application of tolbutamide, by a continuous intravenous drop of a 10% solution of glucose. The values of the growth hormone after application of tolbutamide raised two to fourfold in comparison to the initial value.

[Pathogenetic relationships between obesity and maturity-onset diabetes]. / Die pathogenetischen Beziehungen zwischen Fettsucht und Maturity-onset-Diabetes.

The influences of the biguanide therapy on the behaviour of the glucose tolerance and the reactive IRI-values in obese diabetics were investigated. Apart from this a group treated with sulfonylurea was compared. Here besides the IRI-values the fat parameters were tested. Apart from these investigations the half-life periods of insulin in obese diabetics were established before and after the treatment with biguanides and compared with the half-life period in diabetics treated with insulin. In a small group a tolbutamide test was carried out and the insulin secretion, the STH-values, and the cortisol values were examined. The investigations permitted the conclusion that the increased IRI-levels are to be explained by a hypertrophy of lipocytes, when at the same time the carbohydrate tolerance is reduced. The hypertrophic fat cell needs more insulin for the induction of glucose than the normal lipocyte. By this means also the improvement of the carbohydrate tolerance after reduction of weight is to be explained. Finally it is tried to interpret the behaviour of the fat parameters.

[Immunoglobulin E and its relation to bronchial asthma]. / Immunoglobulin E und seine Beziehungen zum Bronchialasthma

This paper presents a comparison of the levels of IgE in blood serum in a group of healthy persons, a group of persons suffering on asthma bronchiale of an infectious type and of the group of patients suffering in atopic type of asthma bronchiale. The quantitative estimation of IgE in sera was accomplished by the radioimmunoassay "Phadebas IgE Test". The blood levels of IgE of healthy persons and those suffering on infectious asthma bronchiale had no striking differences. The patients suffering on atopic asthma bronchiale showed a tremendous rise of blood IgE, that could be suppressed by the therapeutic application of corticosteroids (Triamcinolon). After the withdrawal of corticosteroids a new rise of blood IgE has been observed. During the application of corticosteroids there was an evident suppression of plasmatic cortisol levels, which rose after their therapeutic withdrawal.