RESUMO
Two new steroid glycosides from the starfish Fromia milleporella collected in the Seychelles were isolated and characterized: milleporoside A, (20R, 24R)-29-O-[3-O-methyl-beta-D-xylopyranosyl-(1-->4)-3-O-methyl-beta-D-xylopyranosyl]-24-ethyl-5alpha-cholestane-3beta,4beta,6alpha,8,15beta,16beta,29-heptaol, and milleporoside B, (20R, 24R)-(22E)-28-O-[3-O-methyl-beta-D-xylopyranosyl-(1-->4)-3-O-methyl-beta-D-xylopyranosyl]-24-methyl-5alpha-cholest-22-ene-3beta,4beta,6alpha,8,15beta,16beta,28-heptaol. The structures of the glycosides were determined from their spectra and a comparison with spectral characteristics of known compounds. These compounds exhibit a moderate cytostatic activity toward the embryos of the sea urchin Strongylocentrotus intermedius.
Assuntos
Antineoplásicos/química , Glicosídeos/química , Estrelas-do-Mar/química , Esteroides/química , Animais , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Embrião não Mamífero/embriologia , Glicosídeos/isolamento & purificação , Glicosídeos/farmacologia , Esteroides/isolamento & purificação , Esteroides/farmacologia , Strongylocentrotus/embriologia , Strongylocentrotus/crescimento & desenvolvimentoRESUMO
After one to four years of participation in an intensive NIMH intervention project, 30 mothers selected because of extreme high risk for difficulties in parenting gave ratings regarding changes they had made in their lives and the services they were offered. They felt that their lives had changes markedly and ranked the caring relationship with the staff clinicians and abstract rather than concrete services as most important. Training and policy implications are discussed.
