[Effects of intrauterine alcohol intoxication on the function of the central nervous system in the progeny]. / Vliianie alkogol'noi intoksikatsii v period vnutriutrobnogo razvitiia na funktsii tsentral'noi nervnoi sistemy potomstva.

Behavior of mature rats, who had been exposed antenatally to intrauterine alcoholic intoxication, was studied in the open field settings, unavoidable swimming and Simonov's emotional resonance situations; their conditioned reflexes of passive and active avoidance were trained, arterial blood pressure was measured, and sleeping patterns examined. It was demonstrated that animals' orientation/exploration activity was reduced, while passive behavior and fear-associated emotions became more prominent, conditioned reflexes were more difficult to form, vegetative autoregulation was disturbed, and insomniac disturbances were in evidence as a result of intrauterine alcoholic intoxication. It is suggested that the above-listed disorders are rooted in hypoxic cerebral changes, induced by pathogenic effects of alcohol on the embryonal and fetal central nervous system.

[Pharmacological correction of experimental alcoholic embryopathy]. / Farmakologicheskaia korrektsiia éksperimental'noi alkogol'noi émbriopatii.

In the experiments on the progeny of ethanol-exposed rats it was shown that consumption of 15% alcohol instead of water during pregnancy resulted in the worsening of shuttlebox avoidance learning and decrease in succinate dehydrogenase activity in the visual and sensorimotor cortex. These data are indicative of cerebral hypoxia during embryogenesis. The injection of synthetic opioid peptide dalargin during critical periods of development (at the end of embryogenesis and early ontogeny) prevented partially the disturbances of higher nervous activity and tissue breathing which were induced by alcohol intoxication. Possible mechanisms of positive dalargin effect are discussed.

[Action of alcohol in chronic emotional pain stress in rats]. / Deistvie alkogolia pri khronicheskom émotsional'no-bolevom stresse u krys.

Male albino rats were exposed to daily emotional painful stress (EPS) for 4 weeks. The arterial blood pressure of the stressed animals increased and the dynamics of the heart rate changed after functional loading (hypokinesis during one or two hours) as compared with the control group. The increase of the heart weight and activation of cytochrome oxidase activity in the cerebral cortex and hippocampus of rats exposed to EPS were also demonstrated. The use of 20% ethyl alcohol instead of drinking water during EPS partially prevented vegetative disturbances and activation of hippocampal cytochrome oxidase and fully prevented the heart hypertrophy and activation of the enzyme in the cortex. Alcoholization resulted in the increased weight of the spleen and brown adipose tissue and thymus involution. A possible mechanism of the antistress action of alcohol linked with normalization of intensified lipid peroxidation under stress is discussed.

[Local hemodynamics of the brain of the white rat at late periods after discontinuation of neurosis-inducing treatment]. / Lokal'naia gemodinamika mozga belykh krys v otdalennye sroki posle otmeny nevrotiziruiushchego vozdeistviia.

In the visual and sensomotor cortical areas of neurotized rats, velocity of local cerebral blood flow (vLCBF) was measured by the method of hydrogen clearance in 4-6 weeks after the termination of neurotization. No significant decrease of vLCBF which had been observed at the late stages of neurotization, was found in the animals under study. However noticeable vLCBF oscillations indicated vegetovascular dystonia. Disturbances in vLCBF controlling system are supposed to be one of remote sequelae of neurotization.

[Possible role of hypoxia and lipid peroxidation in the development of a neurosis-like condition in the rat]. / Vozmozhnaia rol' gipoksii i perekisnogo okisleniia lipidov v razvitii nevrozopodobnogo sostoianiia u krys.

The chronic emotional pain stress resulting in a development of neurosis-like state in rats induced an increase of arterial pressure and change of the cardiac rate dynamics under the conditions of functional load. An increase of cardiac mass was also seen without change of masses of the thymus, adrenal glands and the spleen. The rise of activity of cytochromeoxidase and activation of peroxide lipide oxidation (by malonate dialdehyde level) were observed in the cerebral cortex and the hippocampus of neurotized rats. Injection of antioxidant F-801 before each emotional pain stress trial prevented vegetative disturbances, cardiac hypertrophy, and increase of oxidative activity in the brain. The role of peroxide lipide oxidation and that of the factor of hypoxia in development of disturbances caused by neurotization were discussed.

[Corrective action of an antioxidant in chronic emotional-pain stress in rats]. / Korrigiruiushchee deistvie antioksidanta pri khronicheskom émotsional'no-bolevom stresse u krys.

Chronic emotional painful stress (EPS) in rats brought about blood pressure elevation and changes in the time-course of the heart rate under functional load (hypokinesia for 2 h). There was also an increase in the heart mass and activation of cytochromoxidase in the brain cortex and hippocamp. Chronic administration of the antioxidant F-801 for EPS prevented vegetative disorders, heart hypertrophy and elevation of oxidative activity in the brain. The role of lipid peroxidation and hypoxia in the development of abnormalities caused by neurotization is discussed.