RESUMO
Antioxidant activity of nine [1,2,4]-triazinone derivatives was studied in the work. Our data show that [1,2,4]-triazinone derivatives with benzyl alcohol, propyl alcohol, me-thyl alcohol and tolyl residues in their structure have antioxidant activity in condition of in vitro NO formation. KO-17 compound proved to have the greatest antioxidant activity which exceeded N-acetyl cysteine's one.
Assuntos
Antioxidantes/farmacologia , Encéfalo/efeitos dos fármacos , Óxido Nítrico/química , Estresse Oxidativo/efeitos dos fármacos , Triazinas/farmacologia , Animais , Antioxidantes/química , Encéfalo/enzimologia , Encéfalo/metabolismo , Técnicas In Vitro , Masculino , Modelos Químicos , Estrutura Molecular , Doadores de Óxido Nítrico/química , Ratos , Ratos Wistar , Relação Estrutura-Atividade , Superóxido Dismutase/metabolismo , Triazinas/químicaRESUMO
The biochemical mechanisms of genomoprotective action of the new derivatives of pyridinecarbonic acids--PV-3, PV-4 and PV-6 in the conditions of tetrachloromethane chemical cell damage have been studied. This effect is related to their antioxidant influence on LPO processes in transcriptionally active and repressed chromatin fractions of rat liver cells and partial restoration of these fractions structure which has been destroyed during intoxication. PV-4 possesses the most genoprotective activity among the substances studied.
Assuntos
Antimutagênicos/farmacologia , Tetracloreto de Carbono/farmacologia , Ácido Carbônico/farmacologia , Genoma , Fígado/efeitos dos fármacos , Animais , Ácido Carbônico/química , Masculino , Piridinas/química , Ratos , Ratos WistarRESUMO
Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.
