RESUMO
In experiments with white rats the influence of emotional and pain stress in combination with alimentary hypercholesterolemia on lipid content of membraneous structures of endotheliocytes of endocardium and microvessels of myocardium and their morphological manifestations has been studied. Combination of these etiological factors is followed by accumulation of free cholesterol and free fatty acids within the cells. This results in damage of single endotheliocytes, the most extreme manifestation of which is formation of endothelial bodies (cytoplasts) with development of microclasmatosis and desquamation of these cells.
Assuntos
Vasos Coronários , Endocárdio , Endotélio Vascular , Hipercolesterolemia , Metabolismo dos Lipídeos , Estresse Psicológico , Animais , Cromatografia em Camada Fina , Vasos Coronários/metabolismo , Vasos Coronários/ultraestrutura , Modelos Animais de Doenças , Endocárdio/metabolismo , Endocárdio/ultraestrutura , Células Endoteliais/metabolismo , Células Endoteliais/ultraestrutura , Endotélio Vascular/metabolismo , Endotélio Vascular/ultraestrutura , Hipercolesterolemia/complicações , Hipercolesterolemia/metabolismo , Hipercolesterolemia/patologia , Lipídeos/sangue , Masculino , Microscopia Eletrônica , Miocárdio/metabolismo , Miocárdio/ultraestrutura , Ratos , Estresse Psicológico/complicações , Estresse Psicológico/metabolismo , Estresse Psicológico/patologiaRESUMO
Alimentary hypercholesterolemia, as well as the intensive physical loadings are accompanied diminishing of level of nitrite-anion as compared to the control group of animals. Combination of the intensive physical loadings and hypercholesterolemia results in maximal lowering level of nitrite-anion and more expressed atherosclerotic damage of wall of arteries of experimental rats, and the moderate physical loadings at hypercholesterolemia render an opposite effect.
