Congenital toxoplasmosis among hospitalized infants in Poland in the years 2007-2021: study based on the national hospital registry.

Congenital toxoplasmosis (CT) is a rare entity and it may pose a life-threatening risk for the newborns. The aim of the study was to evaluate the incidence and other selected factors of CT in Poland. Our study is a population-based study on CT patients in 2007-2021. The study was based on 1504 hospitalization records of first-time diagnosis of CT in newborns. In the study group, we observed 763 males (50.7%) and 741 females (49.3%). The mean and median age was 31 days and 10 days, respectively. Based on the hospital registry, the mean annual CT incidence was estimated to be 2.6 per 10,000 live births (95% CI 2.0-3.2 per 10,000 live births). The incidence of CT cases fluctuated over the years 2007-2021, with the highest incidence in 2010 and the lowest one in 2014. There were no statistically significant differences between the incidence of CT in relation to sex or place of residence. The periodic fluctuations in the number of cases of congenital toxoplasmosis indicates the need to develop effective prevention programs to effectively counteract the disease and its consequences.

[The occurrence of leiomyoma cellulare in the surgical material in the Department of Obstetrics and Gynecology of the District Specialty Hospital in Radom]. / Wystepowanie leiomyoma cellulare w materiale poopiracyjnym w Oddziale Ginekologiczno--Polozniczym w Wszs w Radomiu.

DESIGN: It has been decided to estimate frequency of occurrence of leiomyoma cellulare (LC) among women operated because of the myoma and to compare data with bibliography. MATERIALS AND METHODS: 14 cases of LC among 309 women operated in the District Specialty Hospital in Radom because of the uterine myoma, between January 2000 and June 2002 were analysed. Clinical symptoms, patients' age, parity, radiological images, macroscopic traits, type of operation and histopathological features were analysed. Histopathological diagnosis was established according to the valid criteria: mitotic index < 5 MF / 10 DPW, lack of necrosis, little or none atypia. Qualifications to the operation were set on the basis of the gynecological examination, ultrasound examination and histological estimation of the scrapings from the uterus. RESULTS: LC was recognised among 4.53% of the patients operated because of myoma. They were mostly single tumours, of 7.54 cm in diameter (on average) occurring among women aged 41-50. The youngest patient was 29 years old, the oldest--73. No significant differences in prevalence of LC according to parity were stated. Clinical symptoms, ultrasound examination and macroscopic image were typical of myoma and did not indicate suspicion of LC. The most frequent operation was myomectomy (50%) and hysterectomy including appendages (42.86%) CONCLUSIONS: LC is a relatively frequent subtype of myo-levicellular myoma, which can be diagnosed only by microscopic examination. Because of microscopic similarities to other stromic tumours of the body of the uterus and myo-levicellular sarcoma it is necessary to examine a larger number of specimens and to use valid criteria of recognition.