Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
1.
Contemp Clin Trials ; 136: 107383, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37935305

RESUMO

BACKGROUND: Postnatal depression (PND) is a leading cause of illness and death among women following childbirth. Physical inactivity, sedentary behaviour, poor sleep, and sub-optimal diet quality are behavioural risk factors for PND. A feasible, sustainable, and scalable intervention to improve healthy behaviours and reduce PND symptoms among women at postpartum is needed. This study aims to examine the effectiveness of a multi-behavioural home-based program Food, Move, Sleep (FOMOS) for Postnatal Mental Health designed to improve PND symptoms in women at postpartum. METHODS: This randomised clinical trial will recruit 220 Australian women (2-12 months postpartum) experiencing heightened PND symptoms (Edinburgh Postnatal Depression Scale score ≥ 10). Participants will be randomised to FOMOS or wait-list control receiving standard clinical care. FOMOS is a 6-month mobile health (mHealth) intervention targeting diet quality, physical activity, sedentary behaviour, sleep, and mental health. The intervention, informed by the Social Cognitive Theory and incorporating behaviour change techniques defined in the CALO-RE taxonomy and Cognitive Behavioural Treatment of Insomnia, provides exercise equipment, and educational/motivational material and social support via mHealth and social media. Data collection pre-intervention and at 3, 6 and 12 months will assess the primary outcome of PND symptoms and secondary outcomes (diet quality, physical activity, sitting time, sleep quality) using self-report and device measures. Process evaluation will explore acceptability, appropriateness, cost-effectiveness, feasibility, and sustainability via analytic tools, record keeping, interviews, and surveys. DISCUSSION: If effective, FOMOS could be a feasible and potentially scalable management strategy to support improvement of health behaviours and mental health for women with PND symptoms. TRIAL REGISTRATION: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12622001079730p.


Assuntos
Depressão Pós-Parto , Distúrbios do Início e da Manutenção do Sono , Feminino , Humanos , Saúde Mental , Depressão/terapia , Austrália , Terapia Comportamental , Depressão Pós-Parto/prevenção & controle , Depressão Pós-Parto/diagnóstico , Sono , Ensaios Clínicos Controlados Aleatórios como Assunto
2.
J Card Fail ; 29(11): 1564-1570, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37558087

RESUMO

Left ventricular assist device therapy for advanced heart failure is contraindicated if a patient lives in an unsafe environment and recent guidelines declare that "legal history is pertinent for determining personal constraints or financial responsibilities due to parole requirements, pending charges, and possible imprisonment," implying that incarceration would be a contraindication. International guidelines and precedent in the United States establish that medical care for incarcerated persons should match access in the community. We present a case example and practical considerations for advanced heart failure programs faced with the challenge of partnering with patients with heart failure who may be incarcerated and their correctional health systems in the care of their chronic condition. We encourage the heart failure community to not let incarceration be a contraindication to left ventricular assist device therapy.


Assuntos
Insuficiência Cardíaca , Coração Auxiliar , Humanos , Estados Unidos , Prisões , Insuficiência Cardíaca/terapia
5.
Rev. argent. microbiol ; 43(3): 168-175, jun.-set. 2011. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-634687

RESUMO

Las especies del complejo Burkholderia cepacia (CBC) son capaces de causar infecciones crónicas del tracto respiratorio en pacientes con fibrosis quística y en otros individuos inmunocomprometidos. La mayoría de estas especies exhiben alta resistencia a la terapia antibiótica, lo que genera la necesidad de una detección rápida y precisa para poder implementar estrategias de control adecuadas. En este trabajo se utilizó la técnica de reacción en cadena de la polimerasa (PCR) para amplificar el gen recA (PCR-recA), con el fin de identificar microorganismos pertenecientes al CBC. Con este método molecular como referencia, se evaluó la sensibilidad (S) y la especificidad (E) de dos sistemas de identificación comerciales automatizados, VITEK 2 y API 20NE (bioMérieux®), así como también el valor de las pruebas bioquímicas manuales más representativas para la identificación de estos microorganismos. El método VITEK 2 presentó una S del 71,1 % y una E del 100 %; para el método API 20NE, estos valores fueron 69,7 % y 90,2 %, respectivamente. En cuanto a las pruebas fenotípicas manuales, los resultados obtenidos fueron más heterogéneos, lo que posiblemente se deba a que estas bacterias podrían sufrir presión selectiva para sobrevivir en pacientes crónicos y perder factores fenotípicos característicos. La técnica de PCR-recA resultó de fácil implementación, por lo que cabe considerar a esta técnica de identificación como una opción viable, aun en laboratorios de diagnóstico clínico de mediana complejidad.


Species belonging to the Burkholderia cepacia complex (BCC) are capable of causing chronic respiratory tract infections in patients suffering from cystic fibrosis as wel as in immunocompromised individuals. Most of these species are highly resistant to antibiotic therapy, generating the need for their rapid and accurate detection for the proper treatment and clinical management of these patients. In this wok, the polymerase chain reaction (PCR) technique based on the amplification of the recA gene (PCR-recA) was applied for an accurate identification of bacteria belonging to the BCC. Sensitivity (S) and specificity (E) of two biochemically-based commercial automated systems, API 20NE and VITEK 2 (bioMérieux®), and of the most representative biochemical manual tests for the identification of the Burkholderia cepacia complex were herein evaluated. The commercial systems VITEK 2 and API 20NE showed the following sensitivity and specificity vaues for identification to the species level, S: 71.1 %, E: 100 %, S: 69.7 %, E: 90.2 %, respectively. More complex results were observed for phenotypic manual tests, since BCC bacteria can undergo selective pressure to survive in chronic patients causing the loss of their typical phenotypic characteristics. The PCR-recA technique was easy to implement even in medium-complexity clinical diagnostic laboratories.


Assuntos
Humanos , Técnicas de Tipagem Bacteriana/métodos , Infecções por Burkholderia/microbiologia , Complexo Burkholderia cepacia/isolamento & purificação , Kit de Reagentes para Diagnóstico , Infecções Respiratórias/microbiologia , Automação , Proteínas de Bactérias/genética , Infecções por Burkholderia/diagnóstico , Infecções por Burkholderia/etiologia , Colorimetria/métodos , Fibrose Cística/complicações , Suscetibilidade a Doenças , DNA Bacteriano/genética , Genes Bacterianos , Genótipo , Reação em Cadeia da Polimerase/métodos , Padrões de Referência , Reprodutibilidade dos Testes , Recombinases Rec A/genética , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/etiologia , Sensibilidade e Especificidade , Software
6.
Rev Argent Microbiol ; 43(3): 168-75, 2011.
Artigo em Espanhol | MEDLINE | ID: mdl-22430988

RESUMO

Species belonging to the Burkholderia cepacia complex (BCC) are capable of causing chronic respiratory tract infections in patients suffering from cystic fibrosis as well as in immunocompromised individuals. Most of these species are highly resistant to antibiotic therapy, generating the need for their rapid and accurate detection for the proper treatment and clinical management of these patients. In this work, the polymerase chain reaction (PCR) technique based on the amplification of the recA gene (PCR-recA) was applied for an accurate identification of bacteria belonging to the BCC. Sensitivity (S) and specificity (E) of two biochemically-based commercial automated systems, API 20NE and VITEK 2 (bioMérieux®), and of the most representative biochemical manual tests for the identification of the Burkholderia cepacia complex were herein evaluated. The commercial systems VITEK 2 and API 20NE showed the following sensitivity and specificity vaues for identification to the species level, S: 71.1 %, E: 100 %, S: 69.7 %, E: 90.2 %, respectively. More complex results were observed for phenotypic manual tests, since BCC bacteria can undergo selective pressure to survive in chronic patients causing the loss of their typical phenotypic characteristics. The PCR-recA technique was easy to implement even in medium-complexity clinical diagnostic laboratories.


Assuntos
Técnicas de Tipagem Bacteriana/métodos , Infecções por Burkholderia/microbiologia , Complexo Burkholderia cepacia/isolamento & purificação , Kit de Reagentes para Diagnóstico , Infecções Respiratórias/microbiologia , Automação , Proteínas de Bactérias/genética , Infecções por Burkholderia/diagnóstico , Infecções por Burkholderia/etiologia , Colorimetria/métodos , Fibrose Cística/complicações , DNA Bacteriano/genética , Suscetibilidade a Doenças , Genes Bacterianos , Genótipo , Humanos , Reação em Cadeia da Polimerase/métodos , Recombinases Rec A/genética , Padrões de Referência , Reprodutibilidade dos Testes , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/etiologia , Sensibilidade e Especificidade , Software
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...