Snapshot of a social movement: Mental health and protest classes in Hong Kong.

BACKGROUND: Popular protests have broken out worldwide, particularly in the last few years. In 2019, numerous demonstrations against an extradition bill occurred in Hong Kong until pandemic restrictions were imposed. The policing response relied heavily on methods such as batons, tear gas and rubber bullets. Given the relevance for other geographical contexts, the current study investigated the mental health impacts on protest participants and spillover to community members. METHODS: Surveys were disseminated on social media in August and October 2019 to collect demographics, political views, protest participation, exposure to (protest-related) potentially traumatic events (PTEs) and mental health symptoms. A latent class analysis (LCA) was conducted using demographic data and inter-class differences in PTEs and mental health symptoms were examined. RESULTS: There were 37,541 (59.8% female) and 40,703 (50.0% female) responses in August and October. Respondents, even those with low participation, reported significant levels of depression, anxiety, and symptoms of traumatic stress (STS). The LCA suggested a 5-class solution (youth, allies, supporters, sympathizers, and frontliners). Mental health symptoms and PTEs varied with class membership, with 50.8% of frontliners reporting severe STS. LIMITATIONS: The non-random sampling and self-reported measures may over-estimate the prevalence of mental distress in the wider population. CONCLUSIONS: Large numbers of pro-democracy supporters in Hong Kong reported high rates of depression, anxiety and STS during mass protests. Younger and more heavily involved respondents faced the highest mental health risks, however elevated rates were also observed for respondents with low participation.

Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants.

AIM: Spatial deficits are widely observed in normal ageing and early Alzheimer's disease. This review systematically examined neuroimaging evidence for structural and functional differences in the hippocampus (HC) associated with non-pathological age-related changes in allocentric spatial abilities. METHODS: Databases were searched to identify peer-reviewed studies on allocentric spatial processing in normal ageing including MRI or fMRI data. 15 eligible studies were reviewed after applying exclusion criteria and quality assessment. RESULTS: There was a marked deficit in allocentric spatial processing and trend towards egocentric strategies in older adults when compared to young controls or across the lifespan, associated in the majority of studies with HC volumetric changes, metabolic or microstructural indicators, and underactivity. A few studies reported no significant correlations. CONCLUSION: Findings confirm literature supporting an age-related allocentric spatial processing deficit and a shift towards egocentric strategies. A majority of studies implicated HC atrophy, microstructural/metabolic alterations or functional changes in age-related allocentric spatial impairment. More sensitive imaging techniques and ecologically valid spatial tasks are needed to detect subtle changes in the HC and brain's navigational network.

Gender differences in correlates of cognition in first-episode psychosis.

Studies of gender cognitive differences in schizophrenia have reported mixed results. This study examined cognitive correlates including demographics, symptoms and functioning in men and women in a large sample of first-episode adult-onset psychosis patients. Detailed demographic, clinical and functioning data were collected from 360 first-episode patients upon admission into an early intervention service for psychotic disorders. They were also administered a comprehensive neurocognitive battery. Correlation analyses showed that memory and working memory were more significantly associated with onset age, negative symptoms and side effects in women. Processing speed correlated with antipsychotic dosage in men and side effects in women. Selective attention correlated with reality distortion and negative symptoms in women, and onset age and education in men. Executive function correlated with onset age and reality distortion in women. All cognitive domains significantly correlated with educational level and functioning in both genders. Negative symptoms explained significant variability in cognition in both genders, while reality distortion, side effects and affective symptoms were significant factors that differentiated between genders. Although there are similarities in cognitive deficits, considerable heterogeneity exists in associations of symptoms and cognition in men and women. Results facilitate individualised tailoring of interventions, including cognitive remediation therapy.

Verbal working memory in schizophrenia: The role of syntax in facilitating serial recall.

BACKGROUND: Deficits in verbal working memory (VWM) have consistently been observed in schizophrenia, ranging from impairments in capacity, encoding, to irregular semantic organisation. However, syntactic deficits are less well-characterised, despite its crucial role in language construction. This study examines the role of simple syntactic structure (basis of the "sentence superiority effect") in VWM of patients with psychotic disorders. METHODS: Patients with schizophrenia-spectrum disorders (n=40) and healthy controls matched on age, sex and education (n=40) were administered an auditory serial recall task containing word lists with low semantic coherence and either syntactically familiar structure (noun-verb-noun sequence) or syntactically unfamiliar structure. Other neurocognitive measures, symptoms and social functioning of patients were also assessed. RESULTS: A 4-way analysis of variance (group×version×list type×serial position) indicated that patients had significantly worse performance overall, suggesting a generalised verbal memory impairment. In addition, a significant interaction was found for list type and Group, demonstrating that healthy controls, but not patients, had superior performance in syntactically familiar word lists. A subgroup analysis of high-performing patients revealed that the interaction was not an artefact of poor verbal memory, but a selective deficit in syntactic facilitation. CONCLUSIONS: Our findings may suggest segregated mechanisms for maintenance and computational aspects of VWM, and show that even simple syntactic structure facilitates recall of syntactically unfamiliar words lists. Additionally, schizophrenic patients show difficulty utilising syntactic information, which highlights the need to understand the neuropsychological basis of working memory and linguistic impairments in psychosis.