Random Cycle Loss and Its Application to Voice Conversion.

Speech disentanglement aims to decompose independent causal factors of speech signals into separate codes. Perfect disentanglement benefits to a broad range of speech processing tasks. This paper presents a simple but effective disentanglement approach based on cycle consistency loss and random factor substitution. This leads to a novel random cycle (RC) loss that enforces analysis-and-resynthesis consistency, a main principle of reductionism. We theoretically demonstrate that the proposed RC loss can achieve independent codes if well optimized, which in turn leads to superior disentanglement when combined with information bottleneck (IB). Extensive simulation experiments were conducted to understand the properties of the RC loss, and experimental results on voice conversion further demonstrate the practical merit of the proposal. Source code and audio samples can be found on the webpage http://rc.cslt.org.

The mutual constraints of states and global value chains during COVID-19: The case of personal protective equipment.

Shortages of critical medical supplies during the COVID-19 pandemic have turned global value chains (GVCs) in personal protective equipment (PPE) into a political lightning rod. Some blame excessive outsourcing and foreign dependency for causing shortages, thus urging greater state intervention; others applaud GVCs for their flexibility and scaling up of production, while blaming states for undermining GVC operations. Using policy process-tracing and monthly trade data of seven PPE products across the US, Europe, China and Malaysia, this paper goes beyond the binary debate of either the 'failure' or 'success' of GVCs to show when and under what conditions states interacted with GVCs to produce mixed outcomes in provisioning countries with PPEs. We identify interactions between the type of state intervention and two key structural features of GVCs - geographic distribution of production and technological attributes of the product. Conceptually, the paper demonstrates the mutual constraints of states and GVCs, and highlights structural factors involved in the relationship. Looking to the future of GVCs, we caution against wholesale declarations that GVCs should be abandoned or maintained, instead concluding that paying attention to GVC structure, states and their interactions are crucial.

Deconstructing and Historicizing Access to Medicines: The Changing Priority of Pharmaceutical Governance in China.

Securing access to medicines (ATM) is critical for improving public health outcomes. Existing research has long identified and analyzed various barriers that may impede ATM at the global, national, or local levels. However, it tends to adopt a normative perspective to prescribe what infrastructures, resources, and measures should be put in place to improve ATM. Little scholarship has explored how and why countries may prioritize certain dimensions of ATM over others in pharmaceutical governance within specific historical contexts. This article fills that gap by deconstructing and historicizing the concept of ATM. The author aims to make two arguments. First, tensions easily arise between different dimensions of ATM, and prioritizing certain dimensions in pharmaceutical policy may impede improvements in others (e.g., availability vs. affordability). Second, which dimension(s) of ATM might be prioritized in the state's pharmaceutical policy hinges upon social, economic, and political forces. To substantiate these arguments, the author draws on interview and archival evidence from China. Specifically, the author provides a historical account of how and why the priorities of pharmaceutical governance in China changed over time: 1) 1949-late 1970s: pursuing both drug availability and affordability through socialist planning; 2) early 1980s-2015: priority shifting from availability (before the mid-1990s) to affordability (after the mid-1990s); 3) 2015-present: striving for a rebalance between drug availability and affordability.

RETARDED PALEA1 controls palea development and floral zygomorphy in rice.

Poaceae, one of the largest flowering plant families in angiosperms, evolved distinct inflorescence and flower morphology diverging from eudicots and other monocots. However, the mechanism underlying the specification of flower morphology in grasses remains unclear. Here we show that floral zygomorphy along the lemma-palea axis in rice (Oryza sativa) is partially or indirectly determined by the CYCLOIDEA (CYC)-like homolog RETARDED PALEA1 (REP1), which regulates palea identity and development. The REP1 gene is only expressed in palea primordium during early flower development, but during later floral stages is radially dispersed in stamens and the vascular bundles of the lemma and palea. The development of palea is significantly retarded in the rep1 mutant and its palea has five vascular bundles, which is similar to the vascular pattern of the wild-type lemma. Furthermore, ectopic expression of REP1 caused the asymmetrical overdifferentiation of the palea cells, altering their floral asymmetry. This work therefore extends the function of the TCP gene family members in defining the diversification of floral morphology in grasses and suggests that a common conserved mechanism controlling floral zygomorphy by CYC-like genes exists in both eudicots and the grasses.