Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.

PURPOSE: The purpose of this study was to analyze the clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis. METHODS: The methods utilized in this study were prospective analysis of the clinical manifestations, types of seizures, electroencephalogram (EEG), adjuvant examination, treatment and prognosis of 19 cases of LGI1-antibody encephalitis diagnosed from January 2017 to February 2018 in First Affiliated Hospital of Zhengzhou University, and reviewed related literatures. RESULTS: The 15/19 (79%) patients were male, and the average onset age was 58 years (23-82). The following cases were observed: 17 (89%) with epilepsy seizures, 14 (73%) with mental disorders, and 13 (68%) with cognitive impairment. Types of epilepsy were including focal aware seizures, focal-impaired awareness seizures, focal to bilateral tonic-clonic seizures, and status epilepticus. The motor events were most commonly clonus or automatisms, and the sensory events were frequently body shuddering. The 13 patients had faciobrachial dystonic seizures (FBDS); the median frequency was 48 per day (range 5-180). In some video-EEGs, multifocal ictal epileptiform discharges from frontal, temporal, and apical regions, and interictal slow wave activity were observed in patients. Normal EEG appeared in all patients during FBDS. Five patients had hyponatremia, and brain magnetic resonance imaging (MRI) results of 5 cases were abnormal. All patients were treated with antiepileptic drugs and immunotherapy, and their clinical symptoms were improved. During the follow-up period, 13 patients recovered basically, and 6 patients relapsed. One patient died of status epilepticus after relapse. CONCLUSIONS: Faciobrachial dystonic seizure and various types of epileptic seizures are characteristic manifestations of LGI1-antibody encephalitis, which can assist in early diagnosis. Once this has been diagnosed, antiepileptic drugs and immunotherapy should be given as soon as possible to the patient.

Study on relationship between vascular endothelial growth factor and tumor burden / 中国免疫学杂志

Objective:To investigate the relationship between vascular endothelial growth factor ( VEGF ) and tumor burden. Methods: 100 cases of healthy volunteers,high risk of malignancy (family history of malignant tumors),without site lesions in patients with malignant tumor after operation,patients with stable disease after treatment,newly diagnosed malignancies were enrolled respectively,and recorded as control group,high-risk group,operation group,stable group and newly diagnosed group. The serum VEGF levels in the groups were quantitatively detected respectively,and the peripheral blood CD4+and CD8+were measured,then the CD4+/CD8+was calculated. The increasing rates and grading of VEGF, the serum VEGF levels and the CD4+/CD8+values were compared. Results: There was a significant difference in serum VEGF classification among the groups (P＜0. 05). The increasing rates of serum VEGF and the serum VEGF levels in the high-risk group,the operation group,the stable group and the newly diagnosed group were much higher than those in the control group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the control group ( P＜0. 05) . The increasing rates of serum VEGF and the levels of serum VEGF in the operation group,the stable group and the newly diagnosed group were much higher than those in the high-risk group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the high-risk group (P＜0. 05). The increasing rates of serum VEGF and the levels of serum VEGF in the stable group and the newly diagnosed group were much higher than those in the operation group (P＜0. 05),of which the CD4+and CD4+/CD8+values were much lower than those in the operation group (P＜0. 05). The increasing rates of serum VEGF and the level of serum VEGF in the newly diagnosed group were much higher than those in the stable group (P＜0. 05),of which the CD4+and CD4+/CD8+value were much lower than those in the stable group (P＜0. 05). The CD4+levels in the stable group and the newly diagnosed group were much lower than those in the control group,high-risk group,operation group (P＜0. 05). In the newly diagnosed group,serum VEGF level was negatively correlated with CD4+/CD8+(r=-0. 578,P＜0. 05). Conclusion: The level of serum VEGF in patients with malignant tumor increase in varying degrees,which also has certain relationships with cellular immune function,and it has reference value to determine the effect of the control of the tumor.

Preparation and optical properties of Fe3O4 nanoparticles-doped blue phase liquid crystal.

The magnetic Fe3O4 nanoparticle-doped blue phase liquid crystal (BPLC) was found to have a relatively strong contrast ratio in magnetic-addressed display performance compared to the composites in other phases; this is a new application of the BPLC and a way to prepare a new type of power-free magnetically-driven LC flexible display.

Multiresidue analysis of organochlorine pesticides and the application to Chinese herbal medicine / 中国中药杂志

[A review of study on multiresidue analyses of organochlorine pesticides(OCPs) was presented here, which included sample extraction, clean-up and determination. The multiresidue analytical methods applied to Chinese herbal medicine was also discussed.