Assuntos
Aneurisma Coronário/patologia , Estenose Coronária/tratamento farmacológico , Imunossupressores/administração & dosagem , Síndrome de Linfonodos Mucocutâneos/complicações , Sirolimo/administração & dosagem , Stents/efeitos adversos , Criança , Aneurisma Coronário/etiologia , Vasos Coronários/patologia , Feminino , Humanos , Bombas de Infusão ImplantáveisRESUMO
We report our experience in coronary angioplasty on a calcified lesion that was not passable with balloon catheters despite an adequate preangioplasty lumen size on angiogram and intravascular ultrasonography study. The angioplasty was successfully performed with a simple and inexpensive buddy balloon technique.
Assuntos
Angioplastia Coronária com Balão/métodos , Calcinose/terapia , Estenose Coronária/terapia , Idoso , Calcinose/diagnóstico , Cateterismo Cardíaco , Angiografia Coronária , Estenose Coronária/diagnóstico , Humanos , Masculino , Ultrassonografia de IntervençãoRESUMO
Treatment of long, diffuse in-stent restenosis remains a therapeutic challenge. We report the successful use of multiple sirolimus-eluting stents (three 33-mm long stents) in a long, diffuse in-stent restenotic lesion. No major adverse cardiovascular events, including acute/subacute/delayed stent thrombosis, were noted at ten months. Angiography at six months showed widely patent stents with 19% restenosis only at the worst segment.
Assuntos
Materiais Revestidos Biocompatíveis/uso terapêutico , Reestenose Coronária/terapia , Imunossupressores/uso terapêutico , Sirolimo/uso terapêutico , Stents , Idoso , Angioplastia Coronária com Balão , Implante de Prótese Vascular , Angiografia Coronária , Reestenose Coronária/diagnóstico por imagem , Feminino , HumanosRESUMO
BACKGROUND: Severe acute respiratory syndrome (SARS) is characterized by an overaggressive immune response. Myocardial performance may be impaired in cytokine-mediated immune reactions. METHODS AND RESULTS: Forty-six patients with established clinical diagnosis of SARS were studied prospectively. Transthoracic echocardiographic examinations were done at the acute stage of infection and 30 days later. Among them, 14 patients required mechanical ventilation. The clinical course, laboratory data, SARS-CoV antibody titers, and results of reverse transcriptase-polymerase chain reaction were studied. Significantly higher left ventricular index of myocardial performance (IMP) (0.42+/-0.13 versus 0.33+/-0.09, P<0.001), longer isovolumic relaxation time (102.9+/-15.7 versus 81.6+/-14.7 ms, P<0.001), lower flow propagation velocity (69.6+/-15.7 versus 83.8+/-19.7 cm/s, P=0.011), and Doppler-derived cardiac output (4.69+/-1.01 versus 5.49+/-1.04 L/min, P<0.001) were observed during acute infection when compared with those at 30 days. No significant valvular disease or pulmonary hypertension was found. At baseline, a lower mean left ventricular ejection fraction (LVEF) (65.3+/-12.8% versus 71.4+/-5.7%, P=0.03) and a higher mean IMP (0.51+/-0.11 versus 0.40+/-0.12, P=0.017) were found in patients who required mechanical ventilation. A decrease in LVEF correlated moderately with an elevated lactate dehydrogenase level (r=-0.605, P<0.001), whereas a higher IMP correlated weakly with an increase in creatine kinase level (r=0.38, P=0.016). Histological examination of the heart in the patient with the lowest EF (30.2%) revealed no interstitial lymphocytic infiltrate or myocyte necrosis. CONCLUSIONS: Subclinical diastolic impairment without systolic involvement was observed in patients with SARS. This impairment may be reversible on clinical recovery.
Assuntos
Síndrome Respiratória Aguda Grave/fisiopatologia , Função Ventricular Esquerda , Doença Aguda , Adulto , Idoso , Antivirais/uso terapêutico , Terapia Combinada , Convalescença , Diástole , Ecocardiografia , Ecocardiografia Doppler de Pulso , Feminino , Humanos , Masculino , Metilprednisolona/uso terapêutico , Pessoa de Meia-Idade , Estudos Prospectivos , Respiração Artificial , Ribavirina/uso terapêutico , Síndrome Respiratória Aguda Grave/complicações , Síndrome Respiratória Aguda Grave/tratamento farmacológico , Síndrome Respiratória Aguda Grave/terapia , Disfunção Ventricular Esquerda/etiologia , Disfunção Ventricular Esquerda/fisiopatologiaRESUMO
We report a successful carotid angioplasty in a patient with symptomatic and critical aortic stenosis. The safety and feasibility of this technique in this scenario have not been well established and reported. With careful planning and technique, we believe the procedure should be safe and feasible.