AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal.

Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence. A-kinase anchoring protein 150 (AKAP150) expression in NAc is significantly upregulated and contributes to the morphine withdrawal behavior. However, the underlying mechanism of AKAP150 under opioid withdrawal remains unclear. In this study, AKAP150 expression in NAc is upregulated in naloxone-precipitated morphine withdrawal model, and knockdown of AKAP150 alleviates morphine withdrawal somatic signs and improves the performance of conditioned place aversion (CPA) test. AKAP150 in NAc D1R-MSNs is related to modulation of the performance of morphine withdrawal CPA test, while AKAP150 in NAc D2R-MSNs is relevant to the severity of somatic responses. Our results suggest that AKAP150 from D1R-MSNs or D2R-MSNs in NAc contributes to the developmental process of morphine withdrawal but plays different roles in aspects of behavior or psychology.

Children's sensory processing sensitivity and prosocial behaviors: Testing the differential susceptibility theory.

We conducted two studies to investigate whether children (3-6 years old) with high sensory processing sensitivity show greater susceptibility toward environmental influence in their prosocial development. In two independent samples (NStudy 1 = 120, 55 boys, 65 girls; NStudy 2 = 151, 72 boys, 79 girls), we successfully replicated the findings that children with high sensory processing sensitivity, particularly aesthetic sensitivity, demonstrated stronger susceptibility to the influence of negative parenting in their prosocial behaviors. In the laboratory experimental setting (Study 2), we found that children high in sensory processing sensitivity demonstrated stronger susceptibility to observed negative feedback compared to children with low sensitivity. The heightened susceptibility to observed feedback may potentially be attributed to their enhanced emotional reactivity in reaction to environmental stimuli. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Mothers' Depressive Symptoms and Children's Internalizing and Externalizing Behaviors: Examining Reciprocal Trait-State Effects from Age 2 to 15.

Using a large sample from the National Institute of Child Health and Development Study of Early Child Care and Youth Development (N = 1,178, 51% were male and 80% were White), the random intercept cross-lagged panel model was employed to unpack the trait and state aspects in the relations between mothers' depressive symptoms and children's behavioral problems from age 2 to 15. The transactional predictions among mothers' depressive symptoms and children's behavioral problems were largely attributed to their correlations at the underlying trait level (rs = .458-.528). At the state level, the mutual influences among mothers' depressive symptoms and children's behavior problems occurred more often during periods of transition. With that said, the child effects hypothesis was not supported.

The moderating role of sensory processing sensitivity in the link between stress and depression: A VBM study.

This study examined whether components of sensory processing sensitivity (SPS) could moderate the effect of perceived stress on depressive symptoms and its neural substrates. In this study, 244 participants (181females) reported on their SPS, perceived stress, and experienced depressive symptoms, and subsequently underwent a resting-state functional magnetic resonance imaging (RS-fMRI) to explore the neural basis of their SPS characteristics. Behavioral results showed that, compared with individuals low in EOE (i.e., ease of excitation, a sub-dimension of SPS), those high in EOE were more likely to report depressive symptoms under stress. The VBM analysis indicated that EOE was significantly positively correlated with gray matter (GM) volumes of right cerebellum and negatively correlated with GM volumes of right dorsal anterior cingulate cortex (right dACC). Moreover, GM volumes of the two areas moderated the relation between stress and depression. These findings collectively suggest that the structural abnormalities in these regions might account for simulating and experiencing intense emotional reactions frequently among individuals with high EOE. Thus, the accumulation of these negative emotions in reaction to stress may lead to higher probabilities of experiencing depressive symptoms. Taken together, present study shed light on how stress interacted with sensory processing sensitivity to predict depression from the neural perspective.

Transactional effects between parental sensitivity and child social adjustment: Specifying trait-state aspects of parenting.

This study examined the reciprocal relations among maternal sensitivity, paternal sensitivity, and children's social adjustment from 54 months of age to 5th grade. Using a subsample from the National Institute of Child Health and Development Study of Early Child Care and Youth Development (N = 829), we employed an autoregressive latent trajectory model with structured residuals (ALT-SR) to unpack the trait and state aspects in the relations between parental sensitivity and children's social adjustment. After taking into account trait factors, among all the significant autoregressive and cross-lagged paths originally found in the autoregressive cross-lagged panel models, less than one third of them remained significant in the ALT-SR model. More specifically, in the ALT-SR model, more parent-driven effects were observed for fathers and child-driven effects were detected between children's social skills and fathers' sensitivity. Taken together, it appears that parents' central tendency to be sensitive in the long term is a stable trait, and experiences less state-level fluctuations, and these appear to matter more for children's general tendency to show well adjustment as opposed to change over time. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Indulgence and Long Term Orientation Influence Prosocial Behavior at National Level.

The relationships between several Hofstede's cultural dimensions and prosocial behavior at national level have been investigated by some studies. Yet the roles of indulgence versus restraint (IVR) and long-term versus short-term orientation (LTO), two newly established cultural dimensions, have received insufficient interest. This study aimed to investigate whether the World Giving Index (WGI), a national level measure of prosocial behavior (including donating, volunteering, and helping a stranger) provided by Gallup, was affected by IVR and LTO. The results suggested a positive link between IVR and WGI, and a negative link between LTO and helping a stranger. Culture values can in a great extend account for why prosocial behavior varies across countries. Further analysis revealed interactions among IVR, LTO, and individualism versus collectivism (IND). Simple slope analyses found that: (1) a higher level of IND could enhance the positive influence of IVR on prosocial behavior; (2) a lower level of IND could weaken the negative impact of LTO on prosocial behavior; (3) a higher level of IVR could weaken the negative effect of LTO on prosocial behavior.

A Vernonia Diacylglycerol Acyltransferase Can Increase Renewable Oil Production.

Increasing the production of plant oils such as soybean oil as a renewable resource for food and fuel is valuable. Successful breeding for higher oil levels in soybean, however, usually results in reduced protein, a second valuable seed component. This study shows that by manipulating a highly active acyl-CoA:diacylglycerol acyltransferase (DGAT) the hydrocarbon flux to oil in oilseeds can be increased without reducing the protein component. Compared to other plant DGATs, a DGAT from Vernonia galamensis (VgDGAT1A) produces much higher oil synthesis and accumulation activity in yeast, insect cells, and soybean. Soybean lines expressing VgDGAT1A show a 4% increase in oil content without reductions in seed protein contents or yield per unit land area. Incorporation of this trait into 50% of soybeans worldwide could result in an increase of 850 million kg oil/year without new land use or inputs and be worth ∼U.S.$1 billion/year at 2012 production and market prices.