Experimental investigation on the hybrid system of mechanical vapor recompression and hollow fiber vacuum membrane distillation applied for wastewater treatment.

In order to achieve zero discharge and resource utilization of industrial high salt wastewater, a hybrid system of mechanical vapor recompression (MVR) and hollow fiber vacuum membrane distillation (HFVMD) was constructed, and several experiments of air tightness, single working condition and multiple working conditions were carried out with ammonium chloride solution as feed, then thermal economic performance were evaluated via a single factor analysis method. The obtained results showed that the system had excellent airtightness to ensure normal evaporation experiment, and high separation efficiency of 99.9% and lower evaporation energy consumption to achieve high efficient separation by combining the advantages of the hydrophobic membrane evaporation and latent heat recovery in view of MVR and HFVMD technologies. Furthermore, increasing feed temperature and feed flow rate increased evaporation rate and decreased evaporation energy consumption, while increasing feed concentration decreased evaporation rate and increased evaporation energy consumption. Finally, the single factor analysis indicated that total investment cost, annual operation cost and annual evaporation capacity were the main factors while environmental cost and equipment service life were the secondary factors which affected the specific evaporation cost. The above research provides theoretical and experimental bases for the development of the proposed system in the future.

Higher degree of keratinization correlated with severe bone destruction in acquired Cholesteatoma.

BACKGROUND: Acquired cholesteatoma is characterized by hyper-keratinized squamous epithelium and bone destruction. However, direct evidence for hyper-keratinized epidermis promoting bone destruction is lacking. AIMS/OBJECTIVES: To determine whether higher degree of keratinization correlated with severe bone destruction and further offer direct evidence for keratinocyte-inducing osteoclastogenesis. MATERIALS AND METHODS: Histological changes and clinical relevance were analyzed in human-acquired cholesteatoma. Animal models were established by implanting autologous epidermis with different degrees of keratinization. The severity of bone resorption and the number of osteoclasts were compared in different keratinized groups. An in vitro coculture system was developed to mimic the progress of keratinocyte-inducing osteoclastogenesis. RESULTS: The matrix of cholesteatoma was composed of a thicker stratum corneum than normal skin. The stratum corneum thickness and the expression of Keratin 10 positively correlated to the severity of bone destruction. Animal models revealed that the bone destruction induced by a higher keratinized epidermis was more severe. Osteoclasts were detected in bone erosion areas, and the number of osteoclasts increased with the keratinization degrees of the graft. In vitro studies showed that keratinocytes directly promoted monocytes differentiating into osteoclasts. CONCLUSIONS AND SIGNIFICANCE: In acquired cholesteatoma, the degree of keratinization correlated with disease severity, and keratinocytes directly promote osteoclastogenesis.

The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry.

The ligand binding domain (LBD) of retinoid-related orphan nuclear receptor γt (RORγt) has been exploited as a promising target for the new small molecule therapeutics to cure autoimmune diseases via modulating the IL-17 and IL-22 production by Th17 cells. Diverse chemical scaffolds of these small molecules have been discovered by multiple groups with methods such as high throughput screening (HTS) and virtual screening. These different scaffolds are further developed by medicinal chemists to afford lead compounds the best of which enter clinical trials. In this review, we summarize these chemical scaffolds and their evolution paths according to the groups in which they have been discovered or studied. We combine the data of the chemistry, biological assays and structural biology of each chemical scaffold, in order to afford insight to develop new RORγt modulators with higher potency, less toxicity and elucidated working mechanism.

Coherent Enhancement of Dual-Path-Excited Remote SERS.

Combining both localized surface plasmon polaritons (LSPPs) and propagating surface plasmon polaritons, remote surface-enhanced Raman scattering (SERS) emerges as a novel sensing technology in recent years, which could avoid the overlap of incident light and inelastic scattering light in SERS. Compared to traditional SERS, it has novel applications in sensors, plasmon-driven surface-catalyzed reactions, Raman optical activity, etc. However, the weak Raman intensity of remote SERS impedes its further application. In this work, we demonstrated that the remote SERS signals could be enhanced by more than 100% through the subwavelength interference in dual-path-excited Ag-branched nanowire dimer and nanowire-nanoparticle systems. Our experiment has revealed that remote SERS intensities could be modulated by polarization and phase differences of two incident lights illuminating at two separate nanowire terminals. The simulated electromagnetic field distributions through the finite-difference time-domain (FDTD) method indicate that subwavelength interference occurs in Ag nanowires, which causes the Raman intensities collected at a remote site is greatly influenced by the coherent superposition of propagating surface plasmon polaritons (PSPPs). Our work on this coherent enhancement could not only promote the application of remote SERS but also enlarge the research on light manipulating in the subwavelength.

Study on the synthesis and physicochemical properties of starch acetate with low substitution under microwave assistance.

In this study, synthesis and physicochemical properties of starch acetate with low substitution under microwave were studied. A three-level-three-factorial Central Composite Design using Response Surface Methodology (RSM) was employed to optimize the reaction conditions. The optimal parameters are as follows: amount of acetic anhydride of 12%, radiation time of 11min, and microwave power of 100W. These optimal conditions predicted by RSM were confirmed that the degree of substitution (DS) of acetate starch is 0.0691mg/g and the physical and chemical properties of natural corn starch (NCS) and corn starch acetate (ACS) were further studied.The transparency, water separation, water absorption, expansion force, and solubility of ACS low substitution are better than NCS, while the NCS's hydrolysis percentage is higher than ACS, which indicate that the modified corn starch has better performance than native corn starch. The surface morphology of the corn starch acetate was examined by scanning electron microscope (SEM), which showed that it had a smooth surface and a spherical and polygonal shape. However, samples' shape is irregular. Crystal structure was observed by X-ray diffraction, and the ACS can determine the level of microwave technology that can destroy the extent of the crystal and amorphous regions. Fourier transform infrared (FTIR) spectroscopy shows that around 1750cm-1 carbonyl signal determines acetylation bonding successfully.

TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation.

Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the severity of bone destruction. Furthermore, TREM-2 was mainly expressed on dendritic cells (DCs). In human acquired cholesteatoma, the expression of proinflammatory cytokines (IL-1ß, TNF-α and IL-6) and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9) were up-regulated, and their expression levels were positively correlated with TREM-2 expression. Osteoclasts were activated in human acquired cholesteatoma. In an animal model, TREM-2 was up-regulated in mice with experimentally acquired cholesteatoma. TREM-2 deficiency impaired the maturation of experimentally acquired cholesteatoma and protected against bone destruction induced by experimentally acquired cholesteatoma. Additional data showed that TREM-2 up-regulated IL-1ß and IL-6 expression via TLR4 instead of the TLR2 signaling pathway and promoted MMP-2 and MMP-8 secretion and osteoclast activation in experimentally acquired cholesteatoma. Therefore, TREM-2 might enhance acquired cholesteatoma-induced bone destruction by amplifying the inflammatory response via TLR4 signaling pathways and promoting MMP secretion and osteoclast activation.

An Overview of Plant Phenolic Compounds and Their Importance in Human Nutrition and Management of Type 2 Diabetes.

In this paper, the biosynthesis process of phenolic compounds in plants is summarized, which include the shikimate, pentose phosphate and phenylpropanoid pathways. Plant phenolic compounds can act as antioxidants, structural polymers (lignin), attractants (flavonoids and carotenoids), UV screens (flavonoids), signal compounds (salicylic acid, flavonoids) and defense response chemicals (tannins, phytoalexins). From a human physiological standpoint, phenolic compounds are vital in defense responses, such as anti-aging, anti-inflammatory, antioxidant and anti-proliferative activities. Therefore, it is beneficial to eat such plant foods that have a high antioxidant compound content, which will cut down the incidence of certain chronic diseases, for instance diabetes, cancers and cardiovascular diseases, through the management of oxidative stress. Furthermore, berries and other fruits with low-amylase and high-glucosidase inhibitory activities could be thought of as candidate food items in the control of the early stages of hyperglycemia associated with type 2 diabetes.

Eardrum thickening approach for the treatment of patulous Eustachian tube.

This study aims to explore the eardrum thickening approach via cartilage myringoplasty for the cessation of symptoms of patulous Eustachian tube (PET), including autophony, aural fullness and breathing synchronous tinnitus. A total of 12 patients who met the diagnosis criteria of PET were included and given an eardrum patching test preoperatively. Then, myringoplasty with ipsilateral full-thickness tragus cartilage under general anesthesia was performed. All patients were followed up for at least 6 months postoperatively. Gross movements of the eardrum under deep respiration disappeared and symptoms were relieved in all patients during the patching test and at 1 month after surgery. All patients were followed up for a length that varied from 6 months to 5 years postoperatively, which demonstrated sustained satisfactory symptom cessation. PET symptoms may have been possibly caused by the gross outward movements of the acoustic transmission system. The eardrum thickening approach via myringoplasty with full-thickness tragus cartilage can be an accessible choice for PET with permanent satisfactory control of symptoms. Furthermore, the preoperative patching test could be a valid way to predict the outcome of the surgery.