[Temporal specificity in stimulus action during the formation of associative ultrastructural restructurings in cerebral cortex neurons]. / Vremennáia spetsifichnost' v deistvii razdrazhitelei pri formirovanii assotsiativnykh ul'trastrukturnykh perestroek v neironakh kory mozga.

By a method of electronic microscopy morphological characteristics were studied of various components of neurones synapses in the sensorimotor cortical zone of rats at different variants of combined and noncombined repeated microiontophoretic presentation of glutamate and acetylcholine. Significant dependence was found of the character and rate of reorganizations of postsynaptic thickness (PSTh), width of synaptic cleft and length of synapses active zone on temporal relations in transmitters action: significant changes of PSTh thickness appeared only in conditions of combined presentations of stimuli (neurotransmitters); maximum thickening of PsTh was caused by the combined action of glutamate and acetylcholine with 3 s delay of the latter. The hypothesis is suggested that temporal specificity during integration of associated signals action to neurones is determined by kinetics of interacting biochemical regulating mechanisms.

[Changes in the ultrastructure of cortical synapses during exposure to associated neurochemical stimuli]. / Izmeneniia ul'trastruktury kortikal'nykh sinapsov pri vozdeistvii assotsiirovannykh neirokhimicheskikh razdrazhitelei.

Dependence of changes in the postsynaptic density, active zone and synaptic cleft on time relations between the administered associated stimuli was established. Locally applied glutamate and acetylcholine were used as the stimuli.