RESUMO
In modern oncology chemotherapy (CT), along with the surgical technique and radiotherapy is a leader in the treatment of cancer patients. More than 60% of patients receiving chemotherapy at different stages of treatment. Recently, modern chemotherapy has become more urgent personal approach to the choice of drugs and their doses, aimed at reducing the toxicity of chemotherapy. Complications of chemotherapy significantly degrade the effectiveness of the treatment of patients with malignant tumors, because they require lower doses of anticancer drug, or lengthening the intervals between cycles of chemotherapy, which affects treatment outcomes and quality of life. This paper presents a literature review of toxic effects of cytostatic drugs on the gastrointestinal tract.
Assuntos
Antineoplásicos/efeitos adversos , Citostáticos/efeitos adversos , Trato Gastrointestinal/efeitos dos fármacos , Neoplasias/tratamento farmacológico , Corticosteroides/farmacologia , Corticosteroides/uso terapêutico , Trato Gastrointestinal/patologia , Humanos , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/patologia , Náusea/prevenção & controle , Neoplasias/patologia , Antagonistas da Serotonina/farmacologia , Antagonistas da Serotonina/uso terapêutico , Resultado do Tratamento , Vômito/prevenção & controleRESUMO
The cancer recti local recurrence is nonresectable in 50-70% of observations, it is treated using irradiation or chemo-irradiation therapy, which improve the patients quality of life and guarantee the 12-13 mo survival mediana. In subsequent progressing disease cryosurgical method of treatment is applied. The results of it application in 22 patients are presented. The survival mediana had constituted 12 mo, the period of time before subsequent progression of the disease--6 mo. The patients quality of life improvement due to the bleeding stoppage, the tumor destruction, the pain elimination achievement was proved by the ECOG scale changes.
