Efficient CO2 electroreduction to ethanol enabled by tip-curvature-induced local electric fields.

Electrocatalytic reduction of CO2 into multicarbon (C2+) products offers a promising pathway for CO2 utilization. However, achieving high selectivity towards multicarbon alcohols, such as ethanol, remains a challenge. In this work, we present a novel CuO nanoflower catalyst with engineered tip curvature, achieving remarkable selectivity and efficiency in the electroreduction of CO2 to ethanol. This catalyst exhibits an ethanol faradaic efficiency (FEethanol) of 47% and a formation rate of 320 µmol h-1 cm-2, with an overall C2+ product faradaic efficiency (FEC2+) reaching ∼77.8%. We attribute this performance to the catalyst's sharp tip, which generates a strong local electric field, thereby accelerating CO2 activation and facilitating C-C coupling for deep CO2 reduction. In situ Raman spectroscopy reveals an increased *OH coverage under operating conditions, where the enhanced *OH adsorption facilitates the stabilization of *CHCOH intermediates through hydrogen bonding interaction, thus improving ethanol selectivity. Our findings demonstrate the pivotal role of local electric fields in altering reaction kinetics for CO2 electroreduction, presenting a new avenue for catalyst design aiming at converting CO2 to ethanol.

Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule.

PURPOSE: In the local administration methods for treating eye diseases, the application of microneedles has great potential due to the shortcomings of low efficacy and significant side effects of local administration preparations. This article provides ideas for the research on the application of ophthalmic microneedle in the treatment of eye diseases. RESULTS: This article analyzes the physiological structures of the eyes, ocular diseases and its existing ocular preparations in sequence. Finally, this article reviews the development and trends of ocular microneedles in recent years, and summarizes and discusses the drugs of ocular microneedles as well as the future directions of development. At the same time, according to the inspiration of previous work, the concept of "microneedle with spinule" is proposed for the first time, and its advantages and limitations are discussed in the article. CONCLUSIONS: At present, the application of ocular microneedles still faces multiple challenges. The aspects of auxiliary devices, appearance, the properties of the matrix materials, and preparation technology of ophthalmic microneedle are crucial for their application in the treatment of eye diseases.