Design and analysis of a microgripper for trans-scale clamping based on a compliant multistable mechanism.

Piezoelectric actuators commonly used in microgrippers have a small stroke, and their accuracy is reduced by the transmission amplification unit, which leads to a contradiction between the clamping range and the clamping accuracy in existing piezoelectric-actuated microgrippers. This paper proposes a design scheme to divide the total clamping range of the microgripper into segments based on the compliant multistable mechanism (CMM). First, by using the stable equilibrium positions of the CMM, the total clamping range of the microgripper is divided into multiple smaller clamping sub-intervals to accommodate objects of different scales. Then, the theoretical models of the displacement amplification ratio of the microgripper amplification mechanism and the stiffness of the microgripper in different clamping sub-intervals are established, and the force-displacement characteristics of the CMM are analyzed. Next, through finite element simulation, the correctness of the theoretical analyses is verified, and it is shown that objects between 0 µm and 1.650 mm can be clamped using four clamping sub-intervals under a five times displacement amplification ratio. Finally, a microgripper of the CMM consisting of two three-segment fully compliant bistable mechanisms connected in series is designed and machined, and microgripper segmented clamping experiments are conducted. The experimental results demonstrate the feasibility of the design scheme proposed in this paper.

TLR4 polymorphism and periodontitis susceptibility: A meta-analysis.

BACKGROUND: Many primary and secondary studies reported the association between Toll-like receptor 4 (TLR4) polymorphism and periodontitis susceptibility, which mainly focused on TLR4-299A>G or TLR4-399C>T of Caucasian, however, these studies had different conclusions. The aim of this study was to reassess relative studies about TLR4 polymorphism and periodontitis susceptibility, and update meta-analysis. METHODS: We searched the electronic database including CNKI (Chinese National Knowledge Infrastructure), PubMed, Embase, and hand searched relative studies until January 4, 2016. Two authors selected studies according to inclusion and exclusion criteria, assessed studies using Newcastle-Ottawa Scale case control study (NOS), and calculated the combined effect size using STATA software, version 12.0. RESULTS: This meta-analysis included 18 studies, containing 2453 healthy participants and 2987 patients with chronic periodontitis (CP) and 462 patients with aggressive periodontitis (AP). There was a significance between TLR4C>G (rs7873784) allele and CP in Asian, and its recessive model was also significant (for C vs G: odds ratio [OR] = 0.72, 95% confidence interval [CI] = 0.54-0.95, I = 0%; for CC + CG vs GG: OR = 0.66, 95% CI = 0.49-0.89, I = 0%). However, we did not detect any significant relevance between other TLR4 polymorphism and periodontitis susceptibility in overall and subgroup analyses. The sensitive analysis showed that dropping any single studies did not affect the pooled-analysis results. Publication bias was not detected. CONCLUSIONS: The meta-analysis found association between TLR4C>G (rs7873784) allele and CP in Asian and it may passed on to offsprings in the form of recessiveness. However, further studies about the association between TLR4C>G (rs7873784) and CP is warranted to confirm.