CO2-Based Stable Porous Metal-Organic Frameworks for CO2 Utilization.

The transformation of carbon dioxide (CO2) into functional materials has garnered considerable worldwide interest. Metal-organic frameworks (MOFs), as a distinctive class of materials, have made great contributions to CO2 capture and conversion. However, facile conversion of CO2 to stable porous MOFs for CO2 utilization remains unexplored. Herein, we present a facile methodology of using CO2 to synthesize stable zirconium-based MOFs. Two zirconium-based MOFs CO2-Zr-DEP and CO2-Zr-DEDP with face-centered cubic topology were obtained via a sequential desilylation-carboxylation-coordination reaction. The MOFs exhibit excellent crystallinity, as verified through powder X-ray diffraction and high-resolution transmission electron microscopy analyses. They also have notable porosity with high surface area (SBET up to 3688 m2 g-1) and good CO2 adsorption capacity (up to 12.5 wt %). The resulting MOFs have abundant alkyne functional moieties, confirmed through 13C cross-polarization/magic angle spinning nuclear magnetic resonance and Fourier transform infrared spectra. Leveraging the catalytic prowess of Ag(I) in diverse CO2-involved reactions, we incorporated Ag(I) into zirconium-based MOFs, capitalizing on their interactions with carbon-carbon π-bonds of alkynes, thereby forming a heterogeneous catalyst. This catalyst demonstrates outstanding efficiency in catalyzing the conversion of CO2 and propargylic alcohols into cyclic carbonates, achieving >99% yield at room temperature and atmospheric pressure conditions. Thus, this work provides a dual CO2 utilization strategy, encompassing the synthesis of CO2-based MOFs (20-24 wt % from CO2) and their subsequent application in CO2 capture and conversion processes. This approach significantly enhances overall CO2 utilization.

Kinetic Process with Anti-Frenkel Disorder in a CsPbI3 Perovskite.

Halide perovskites are rich in ionic diffusion phenomena due to their low activation energy. The soft lead iodide lattice can, in theory, endow the system with more complex defect collaborative motions. In this work, we systematically investigated the hopping mechanics of iodide interstitials with respect to various defect behaviors, such as anti-Frenkel disorder creation and annihilation. We found that the existence of iodide vacancies and interstitials can effectively lower the creation barrier of additional anti-Frenkel disorder in the halide perovskite. The free energy barriers for generating additional Frenkel defect pairs vary from 0.25 to 0.43 eV, in the proximity of those of the original iodide defects at 300 K. This finding suggests that the spontaneous creation of a specific level of anti-Frenkel disorder facilitates long-range annihilation and defect hopping processes.

Toward stabilization of formamidinium lead iodide perovskites by defect control and composition engineering.

Phase instability poses a serious challenge to the commercialization of formamidinium lead iodide (FAPbI3)-based solar cells and optoelectronic devices. Here, we combine density functional theory and machine learning molecular dynamics simulations, to investigate the mechanism driving the undesired α-δ phase transition of FAPbI3. Prevalent iodine vacancies and interstitials can significantly expedite the structural transition kinetics by inducing robust covalency during transition states. Extrinsically, the detrimental roles of atmospheric moisture and oxygen in degrading the FAPbI3 perovskite phase are also rationalized. Significantly, we discover the compositional design principles by categorizing that A-site engineering primarily governs thermodynamics, whereas B-site doping can effectively manipulate the kinetics of the phase transition in FAPbI3, highlighting lanthanide ions as promising B-site substitutes. A-B mixed doping emerges as an efficient strategy to synergistically stabilize α-FAPbI3, as experimentally demonstrated by substantially higher initial optoelectronic characteristics and significantly enhanced phase stability in Cs-Eu doped FAPbI3 as compared to its Cs-doped counterpart. This study provides scientific guidance for the design and optimization of long-term stable FAPbI3-based solar cells and other optoelectronic devices through defect control and synergetic composition engineering.

Is occupational noise associated with arthritis? Cross-sectional evidence from US population.

BACKGROUND: The impact of occupational noise exposure on various diseases, including ear and cardiovascular diseases, has been studied extensively. Nevertheless, the connection between osteoarthritis (OA) and rheumatoid arthritis (RA) and occupational noise exposure remains largely unexplored in real-world scenarios. This study assessed the association between occupational noise exposure and the prevalence of two types of arthritis. METHODS: This study used database data from 2005 to 2012 and 2015-March 2020 from the prepandemic National Health and Nutrition Examination Survey (NHANES) related to occupational noise exposure and arthritis. Multivariate logistic regression analysis was used to estimate the association between occupational noise exposure and RA/OA, adjusting for age, gender, race, education level, marital status, the ratio of family income to poverty, trouble sleeping, smoking status, alcohol consumption, diabetes, hypertension, body mass index (BMI), metabolic equivalents (METs), and thyroid disease. RESULTS: This study included 11,053 participants. Multivariate logistic regression analysis demonstrated that previous exposure to occupational noise was positively associated with self-reported RA (OR = 1.43, 95% CI = 1.18-1.73) and OA (OR = 1.25, 95% CI = 1.07-1.46). Compared to individuals without a history of occupational noise exposure, those with an exposure duration of 1 year or greater exhibited higher odds of prevalent RA, though there was no apparent exposure response relationship for noise exposure durations longer than 1 year. The results of our subgroup analyses showed a significant interaction between age and occupational noise exposure on the odds of self-reported prevalent OA. CONCLUSIONS: Our findings suggest an association between occupational noise exposure and the prevalence of RA and OA. Nevertheless, further clinical and basic research is warranted to better explore their associations.

MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells.

Long non-coding RNAs (lncRNAs) are involved in the pathogenesis of hepatocellular carcinoma (HCC). This study aimed to investigate the potential of MIR222HG in HCC. HCC cells were co-cultured with U937 cells. Gene expression was determined using reverse transcription-quantitative (RT-q) PCR and western blot. Functional analysis was performed using Cell Counting Kit 8 (CCK-8), colony formation, and flow cytometry assays. We found that MIR222HG was overexpressed in HCC patients as well as HepG2 and Huh7 cells. MIR222HG-mediated upregulation of autophagy related 5 (ATG5) promoted tumor cell autophagy and the activation of M2-like tumor-associated macrophages (TAM2). Moreover, MIR222HG-mediated the activation of TAM2 drove the proliferation of HCC cells. Additionally, MIR222HG increased the mRNA expression as well as promoted the mRNA stability of ATG5 via binding to lin-28 homolog B (LIN28B). In conclusion, MIR222HG-mediated autophagy and the activation of TAM2 promote the aggressiveness of HCC cells via regulating LIN28B/ATG5 signaling.

Amino Acid Derivatives of Ginsenoside AD-2 Induce HepG2 Cell Apoptosis by Affecting the Cytoskeleton.

AD-2 (20(R)-dammarane-3ß, 12ß, 20, 25-tetrol, 25-OH-PPD) was structurally modified to introduce additional amino groups, which can better exert its anti-tumor effects in MCF-7, A549, LoVo, HCT-116, HT -29, and U-87 cell lines. We investigated the cellular activity of 15 different AD-2 amino acid derivatives on HepG2 cells and the possible mechanism of action of the superior derivative 6b. An MTT assay was used to detect the cytotoxicity of the derivatives. Western blotting was used to study the signaling pathways. Flow cytometry was used to detect cell apoptosis and ghost pen peptide staining was used to identify the changes in the cytoskeleton. The AD-2 amino acid derivatives have a better cytotoxic effect on the HepG2 cells than AD-2, which may be achieved by promoting the apoptosis of HepG2 cells and influencing the cytoskeleton. The derivative 6b shows obvious anti-HepG2 cells activity through affecting the expression of apoptotic proteins such as MDM2, P-p53, Bcl-2, Bax, Caspase 3, Cleaved Caspase 3, Caspase 8, and NSD2. According to the above findings, the amino acid derivatives of AD-2 may be developed as HepG2 cytotoxic therapeutic drugs.

One new prenylated flavonoid with cytotoxic activity from Epimedium brevicornu maxim.

One previously undescribed prenylated flavonoid (1) and three known ones (2-4) were isolated from leaves of Epimedium brevicornu maxim. Their structures were determined through extensive spectroscopic analysis and comparison with the NMR data in the literature. Compound 1 showed a moderate cytotoxicity with an IC50 value of 18.7 µM, while known compounds 2 and 3 elicited weak cytotoxicities with IC50 values of 29.2 and 32.8 µM against Lewis Lung cancer cells (LLC cells), respectively.

Highly Stable and Efficient Formamidinium-Based 2D Ruddlesden-Popper Perovskite Solar Cells via Lattice Manipulation.

Formamidinium (FA)-based 2D perovskites have emerged as highly promising candidates in solar cells. However, the insertion of 2D spacer cations into the perovskite lattice concomitantly introduces microstrain and unfavorable orientations that hinder efficiency and stability. In this study, by finely tuning the FA-based 2D perovskite lattice through spacer cation engineering, a stable lattice structure with balanced distortion, microstrain relaxation, and reduced carrier-lattice interactions is achieved. These advancements effectively stabilize the inherently soft lattice against light and thermal-aging stress. To reduce the photocurrent loss induced by undesired crystal texture, a polarity-matched molecular-type selenourea (SENA) additive is further employed to modulate the crystallization kinetics. The introduction of the SENA significantly inhibits the disordered crystallization induced by spacer cations and drives the templated growth of the quantum well structure with a vertical orientation. This controlled crystallization process effectively reduces crystal defects and enhances charge separation. Ultimately, the optimized FA-based perovskite photovoltaic devices achieve a remarkable power conversion efficiency (PCE) of 20.03% (certified steady-state efficiency of 19.30%), setting a new record for low-n 2D perovskite solar cells. Furthermore, the devices exhibit less than 1% efficiency degradation after operating at maximum power point for 1000 h and maintain excellent stability after thermal aging and cycles of cold-warm shock, respectively.

Mechanically Gated Transistor.

Silicon-based field effect transistors have underpinned the information revolution in the last 60 years, and there is a strong desire for new materials, devices, and architectures that can help sustain the computing power in the age of big data and artificial intelligence. Inspired by the Piezo channels, a mechanically gated transistor abandoning electric gating altogether, achieving an ON/OFF ratio over three orders of magnitude under a mechanical force of hundreds of nN is developed. The two-terminal device utilizes flexoelectric polarization induced by strain gradient, which modulates the carrier concentration in a Van der Waals structure significantly, and it mimics Piezo channels for artificial tactile perception. This simple device concept can be easily adapted to a wide range of semiconducting materials, helping promote the fusion between mechanics and electronics in a similar way as mechanobiology.

Oxygen doped graphite carbon nitride as efficient metal-free catalyst for peroxymonosulfate activation: Performance, mechanism and theoretical calculation.

In this study, oxygen-doped graphitic carbon nitride (g-C3N4), named O-g-C3N4, was successfully fabricated and characterized, and its performance in activating peroxymonosulfate (PMS, HSO5-) for the removal of phenol, 2,4-dichlorophenol (2,4-DCP), bisphenol A (BPA), rhodamine B (RhB), reactive brilliant blue (RBB) and acid orange 7 (AO7) was evaluated. The catalytic performance of O-g-C3N4 for AO7 removal increased by 14 times compared to g-C3N4. In the presence of 0.2 g L-1 O-g-C3N4, 3.5 mM PMS at natural pH 5.8, 96.4% of AO7 could be removed in 60 min, reduced toxicity of the treated AO7 solution was obtained, and the mineralization efficiency was 47.2% within 120 min. Density functional theory (DFT) calculations showed that the charge distribution changed after oxygen doping, and PMS was more readily adsorbed by O-g-C3N4 with the adsorption energy (Eads) of -0.855 kcal/mol than that of the pristine g-C3N4 (Eads: -0.305 kcal/mol). Mechanism investigation implied that AO7 was primarily removed by the sulfate radicals (SO4•-) and hydroxyl radicals (•OH) on the surface of O-g-C3N4, but the role of singlet oxygen (1O2) to AO7 elimination was negligible. The results of cyclic experiments and catalyst characterization after reaction confirmed the favorable catalytic activity and structural stability of O-g-C3N4 particles. Furthermore, the O-g-C3N4/PMS system was very resistant to most of the environmental impacts, and AO7 removal was still acceptable in natural water environment. This study may provide an efficient metal-free carbonaceous activator with low dosage for PMS activation to remove recalcitrant organic pollutants (ROPs).

Origin of Enhanced Nonradiative Carrier Recombination Induced by Oxygen in Hybrid Sn Perovskite.

Oxygen ingression has been shown to substantially decrease the carrier lifetime of Sn-based perovskites, behind which the mechanism remains yet unknown. Our first-principles calculations reveal that in prototypical MASnI3 (MA = CH3NH3), oxygen by itself is not a recombination center. Instead, it tends to form substitutional OI through combining with native I vacancies (VI) and remarkably increases the original recombination rate of VI by 2-3 orders of magnitude. This rationalizes the experimentally observed sharp decline of carrier lifetime in perovskites exposed to air. The significantly enhanced carrier recombination is due to a smaller electron capture barrier of OI, resulting from lattice strengthening and the suppressed structural relaxation upon electron capture. These insights offer a route to further improve device performance via anion engineering in broad Sn-based perovskite optoelectronics operating in ambient air. Moreover, our results highlight the important role of lattice relaxation for nonradiative carrier capture in materials in general.

Global Landscape of Alternative Splicing in Maize Response to Low Temperature.

Maize (Zea mays L.) is an important food crop planted across the world, and low-temperature stress can affect maize germination. Alternative splicing (AS) is widely present in plants under abiotic stress; however, the response of AS to low-temperature stress in maize remains unclear. In this study, a genome-wide analysis of AS during maize response to low temperatures was performed. AS events were distributed on each chromosome, approximately 2.05-2.09 AS events per gene. Seven genes only had AS in low-temperature-resistant inbred lines. A total of 278 KEGGs and 46 GOs were enriched based on overlapping AS genes, which were associated with hormone and oxidoreductase activity. The mutant was used to verify the function of AS gene ZmWRKY48, and the RGR, RSL, RRL, and RRSA of the mutant decreased by 15.16%-19.87% compared with the normal line. These results contribute to subsequent analysis of the regulatory mechanism of maize in response to low-temperature stress.

Eco-Sustainable Magnesium Oxychloride Cement Pastes Containing Waste Ammonia Soda Residue and Fly Ash.

Magnesium oxychloride cement (MOC), a type of special construction material, has drawn much research attention in solid waste utilization and environmental protection due to its eco-friendly production. Ammonia soda residue (ASR), a by-product generated from sodium carbonate manufacturing, is one of the industrial wastes that can be recycled in MOC systems. However, ASR exhibits adverse effects on the fresh performance and volume stability of MOC pastes. This paper aims at improving the properties of ASR-MOC by introducing fly ash (FA), solid waste from the power industry. Firstly, the roles of FA in MOC pastes are evaluated and analyzed. Then, three substitution ratios of FA (33.3%, 50% and 66.7% in weight) for ASR are designed for MOC pastes with 10% to 40% industrial wastes. Flowability, setting, strength and expansion of all mixtures were experimentally studied. Furthermore, X-ray diffraction (XRD) and scanning electron microscope (SEM) approaches were adopted to illustrate the microstructure changes. Results show that by adding different amounts of FA, the inferior flowability of MOC caused by ASR can be improved by 6-23%, the setting process can be prolonged by 30-55% and the expansion ratio can be reduced by 14-66%. The intensity of characteristic peaks of 5-phase and Mg(OH)2, together with the degrees of crystallization in XRD curves, well explain the strength variation and volume stability of ASR-MOC pastes. According to the regulation of relative specification, up to 20% of solid wastes in weight (10% FA + 10% ASR) can be consumed, contributing greatly to the greener sustainable development of construction materials.

A strong anti-noise segmentation algorithm based on variational mode decomposition and multi-wavelet for wearable heart sound acquisition system.

Wearable devices have now been widely used in the acquisition and measurement of heart sound signals with good effect. However, the wearable heart sound acquisition system (WHSAS) will face more noise compared with the traditional system, such as Gaussian white noise, powerline interference, colored noise, motion artifact noise, and lung sound noise, because users often wear these devices for running, walking, jumping or various strong noise occasions. In a strong noisy environment, WHSAS needs a high-precision segmentation algorithm. This paper proposes a segmentation algorithm based on Variational Mode Decomposition (VMD) and multi-wavelet. In the algorithm, various noises are layered and filtered out using VMD. The cleaner signal is fed into multi-wavelet to construct a time-frequency matrix. Then, the principal component analysis method is applied to reduce the dimension of the matrix. After extracting the high order Shannon envelope and Teager energy envelope of the heart sound, we accurately segment the signals. In this paper, the algorithm is verified through our developing WHSAS. The results demonstrate that the proposed algorithm can achieve high-precision segmentation of the heart sound under a mixed noise condition.

Regulation of Magnetocaloric Effect in Ni40Co10Mn40Sn10 Alloys by Using a Homemade Uniaxial Strain Pressure Cell.

In this study, a homemade uniaxial strain pressure cell was designed to be directly used in the standard magnetometers whereby the magnetic properties of samples subjected to a uniaxial strain and magnetic field were characterized. Its feasibility has been demonstrated by the uniaxial strain control of the phase transition and magnetocaloric effect in Ni40Co10Mn40Sn10 (NCMS) alloys. With the assistance of a uniaxial strain of ~0.5%, the cooling temperature span of NCMS alloys is broadened by 2 K, and the refrigeration capacity under a 3 T magnetic field change increases from 246 to 277 J/kg. This research provides not only direct experimental assistance for the tuning of phase transition by the uniaxial strain but also possibilities for studying the coupled caloric effect in first-order phase transition materials under a combined uniaxial strain and magnetic field by the thermodynamic analysis.

Minimizing and Controlling Hydrogen for Highly Efficient Formamidinium Lead Triiodide Solar Cells.

Formamidinium lead triiodide (FAPbI3) currently holds the record conversion efficiency in the single-junction perovskite solar cell. Iodine management is known to be essential to suppress defect-induced nonradiative losses in FAPbI3 active layers. However, the origin of nonradiative losses and the underlying mechanism of suppressing such losses by iodine-concentration management remain unknown. Here, through first-principles simulation, we demonstrate that native point defects are not responsible for the nonradiative losses in FAPbI3. Instead, hydrogen ions, which can be abundant under both iodine-rich and iodine-poor conditions in FAPbI3, act as efficient nonradiative recombination centers and are proposed to be responsible for the suppressed power conversion efficiency. Moreover, iodine-moderate synthesis conditions can favor the formation of electrically inactive molecular hydrogen, which can dramatically suppress the detrimental hydrogen ions. This work identifies the dominant nonradiative recombination centers in the widely used FAPbI3 layers and rationalizes how the prevailing iodine management reduces the nonradiative losses. Minimizing the unintentional hydrogen incorporation in the perovskite is critical for achieving high device performance.

Genome-Wide Profiling of Alternative Splicing and Gene Fusion during Rice Black-Streaked Dwarf Virus Stress in Maize (Zea mays L.).

Rice black-streaked dwarf virus (RBSDV) causes maize rough dwarf disease (MRDD), which is a viral disease that significantly affects maize yields worldwide. Plants tolerate stress through transcriptional reprogramming at the alternative splicing (AS), transcriptional, and fusion gene (FG) levels. However, it is unclear whether and how AS and FG interfere with transcriptional reprogramming in MRDD. In this study, we performed global profiling of AS and FG on maize response to RBSDV and compared it with transcriptional changes. There are approximately 1.43 to 2.25 AS events per gene in maize infected with RBSDV. GRMZM2G438622 was only detected in four AS modes (A3SS, A5SS, RI, and SE), whereas GRMZM2G059392 showed downregulated expression and four AS events. A total of 106 and 176 FGs were detected at two time points, respectively, including six differentially expressed genes and five differentially spliced genes. The gene GRMZM2G076798 was the only FG that occurred at two time points and was involved in two FG events. Among these, 104 GOs were enriched, indicating that nodulin-, disease resistance-, and chloroplastic-related genes respond to RBSDV stress in maize. These results provide new insights into the mechanisms underlying post-transcriptional and transcriptional regulation of maize response to RBSDV stress.

Hydrogen-Anion-Induced Carrier Recombination in MAPbI3 Perovskite Solar Cells.

Identification and passivation of defect-induced electron-hole recombination centers are currently crucial for improving the efficiency of hybrid perovskite solar cells. Besides general intrinsic defects, experimental reports have indicated that hydrogen interstitials are also abundant in hybrid perovskite layers; however, few reports have evaluated the effect of such defects on the charge carrier recombination and device efficiencies. Here, we reveal that under I-poor synthesis conditions, the negatively charged monatomic hydrogen interstitial, Hi-, will form in the prototypical CH3NH3PbI3 perovskite layer, acting as a detrimental deep-level defect, which leads to efficient electron-hole recombination and lowers the cell performance. We further rationalize that Br doping can mitigate the large atomic displacement caused by the presence of Hi- and hence suppress the formation of the deep localized state. The results advance the knowledge of the deep-level defects in hybrid perovskites and provide useful information for enhancing solar cell performance by defect engineering.

Distribution and Clearance of Blood Constituents after Intracerebral Hemorrhage in Rats: Mechanisms and Relevance for Functional Outcomes.

Background and Objective To evaluate the impact of blood clearance mechanisms on neurologic damage and functional outcomes after intracerebral hemorrhage (ICH) in rats. Methods A rat model of ICH was established through pre-cannulation and injection of autologous arterial blood into the caudate nucleus. Blood was supplemented with 6-amino-caproic acid (a procoagulant), low-molecular-weight heparin (an anticoagulant), or vehicle. Relationships between hematoma volume and edema size and neurologic damage were assessed at different times. Results At 6 hours and 24 hours, hematoma volume was greater in rats that received anticoagulant than in the other two groups (p < 0.01). No significant differences were observed at 3 days, 5 days, or 7 days (p > 0.05). At 6 hours and 24 hours, the Neurological Severity Score in the procoagulant group was significantly higher than in the other two groups (comparison between groups, p < 0.01); and no significant differences were found at other times (p > 0.05). Conclusion Enhanced clearance of leaked blood was associated with larger hematomas within the first 3 days of ICH and with less neurologic damage. The capacity to clear blood is an important determinant of functional recovery after ICH. Enhanced clearance may help reduce neurologic damage.