RESUMO
PURPOSE: To assess the relationships between refractive error and ocular and general parameters in Taiwanese junior high school students and to identify the predictive factors associated with the changes in refractive error. METHODS: This was a prospective, school-based study. A total of 687 students (357 boys and 330 girls) from a municipal junior high school in Taipei were enrolled. The students' refractive status, intraocular pressure, and ocular parameters were measured first in 2010 and again 1 year later. Data were analyzed using multiple linear regression models and generalized estimating equations (GEEs). RESULTS: Significant differences were found between the baseline (2010) and 1-year follow-up (2011) mean anterior chamber depths, mean axial lengths, and mean horizontal and vertical corneal refractive powers. GEE models revealed that vertical and horizontal corneal refractive powers, axial length, and anterior chamber depth were significantly associated with refractive error change. CONCLUSIONS: Students with a longer axial length, steeper corneal radius, and shallower anterior chamber depth had an increased risk of myopic refractive errors.
Assuntos
Câmara Anterior/patologia , Comprimento Axial do Olho/patologia , Córnea/fisiopatologia , Miopia/fisiopatologia , Refração Ocular/fisiologia , Adolescente , Povo Asiático , Feminino , Humanos , Pressão Intraocular/fisiologia , Masculino , Estudos Prospectivos , Estudantes , Taiwan , Acuidade Visual/fisiologiaAssuntos
Inibidores da Angiogênese/efeitos adversos , Anticorpos Monoclonais Humanizados/efeitos adversos , Isquemia Encefálica/induzido quimicamente , Acidente Vascular Cerebral/induzido quimicamente , Idoso , Idoso de 80 Anos ou mais , Bevacizumab , Isquemia Encefálica/diagnóstico , Estudos de Casos e Controles , Feminino , Humanos , Injeções Intravítreas , Degeneração Macular/tratamento farmacológico , Edema Macular/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidoresRESUMO
Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).
