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Nat Prod Res ; 37(13): 2243-2247, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35147448

RESUMO

A new antifungal butenolide irperide (1) along with five known compounds were isolated from the co-culture of endophyte Irpex lacteus and pathogenic Nigrospora oryzae. The structure of 1, including the absolute configuration, was elucidated by analysis of NMR, HR-ESI-MS data and ECD spectra. Compounds 1, 4 and 6 exhibited significant antifungal activity against Aspergillus fumigatus, with MIC values of 1, 2 and 1 µg/mL, respectively.


Assuntos
Antifúngicos , Ascomicetos , Antifúngicos/farmacologia , Antifúngicos/química , Ascomicetos/química
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