1.
Angew Chem Int Ed Engl
; 55(42): 13263-13266, 2016 10 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27633484
RESUMO
Nannocystinâ A, a structurally unique 21-membered macrocyclic depsipeptide with low nanomolar inhibitory activity against elongation factorâ 1A, was synthesized according to a strategy involving the vinylogous Mukaiyama aldol reaction, Sharpless epoxidation, olefin metathesis, the Mitsunobu reaction, and a palladium-catalyzed intramolecular Suzuki coupling of a highly complex cyclization substrate. The overall synthesis is efficient and paves the way for preparation of analogues for drug development efforts.