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Sci Rep ; 11(1): 20490, 2021 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-34650180

RESUMO

This study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.


Assuntos
Coeficiente de Natalidade , Transferência Embrionária/métodos , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Adulto , China , Estudos de Coortes , Feminino , Fertilização in vitro , Humanos , Infertilidade Feminina/terapia , Síndrome do Ovário Policístico , Gravidez , Estudos Retrospectivos , Injeções de Esperma Intracitoplásmicas
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