New exploration of signal detection of Regional Risks from the perspective of data mining: a pharmacovigilance analysis based on spontaneous reporting data in Zhenjiang, China.

BACKGROUND: This study aimed to adopt the conventional signal detection methods to explore a new way of risk identification and to mine important drug risks from the perspective of big data based on Zhenjiang Adverse Event Reporting System (ZAERS). RESEARCH DESIGN AND METHODS: Data were extracted from ZAERS database between 2012 and 2022. The risks of all the reported drug event combinations were identified at the preferred term level and the standardized MedDRA query level using disproportionality analysis. Then, we conducted signal assessment according to the descriptions of drug labels. RESULTS: In total 41,473 ADE were reported and there were 12 risky signals. Signal assessment indicates the suspected causal associations in clindamycin-taste and smell disorders, valsartan-hepatic enzyme increased and valsartan-edema peripheral; the specific manifestations of allergic reactions triggered by clindamycin, cefotaxime, cefazodime, ShexiangZhuanggu plaster, ShexiangZhuifeng plaster, and Yanhuning need to be refined in drug labels. In addition, the drug labels of NiuHuangShangQing tablet/capsule, Fuyanxiao capsule, and BiYanLing tablet should be improved. CONCLUSIONS: In this study, we attempted a new way to find potential drug risks using small spontaneous reporting data. Our findings also suggested the need for more precise identification of allergic risks and the improvement of traditional Chinese medicine labels.

Preparation and corrosion resistance of superhydrophobic Ni-Co-Al2O3 coating on X100 steel.

X100 steel is easy to be corroded because of the high salt content in alkaline soils. The Ni-Co coating can slow down the corrosion but still cannot meet the requirements of modern demands. Based on this, in this study, on the basis of adding Al2O3 particles to the Ni-Co coating to strengthen its corrosion resistance, combined with superhydrophobic technology to inhibit corrosion, a micro/nano layered Ni-Co-Al2O3 coating with a new combination of cells and papillae was electrodeposited on X100 pipeline steel, and superhydrophobicity was integrated into it using a low surface energy modification method to improve wettability and corrosion resistance. SEM, XRD, XPS, FTIR spectroscopy, contact angle, and an electrochemical workstation were used to investigate the superhydrophobic materials' microscopic morphology, structure, chemical composition, wettability, and corrosion resistance. The co-deposition behavior of nano Al2O3 particles can be described by two adsorption steps. When 15 g L-1 nano Al2O3 particles were added, the coating surface became homogeneous, with an increase in papilla-like protrusions and obvious grain refinement. It had a surface roughness of 114 nm, a CA of 157.9° ± 0.6°, and -CH2 and -COOH on its surface. The corrosion inhibition efficiency of the Ni-Co-Al2O3 coating reached 98.57% in a simulated alkaline soil solution, and the corrosion resistance was significantly improved. Furthermore, the coating had extremely low surface adhesion, great self-cleaning ability, and outstanding wear resistance, which was expected to expand its application in the field of metal anticorrosion.

Fractional Fourier Image Transformer for Multimodal Remote Sensing Data Classification.

With the recent development of the joint classification of hyperspectral image (HSI) and light detection and ranging (LiDAR) data, deep learning methods have achieved promising performance owing to their locally sematic feature extracting ability. Nonetheless, the limited receptive field restricted the convolutional neural networks (CNNs) to represent global contextual and sequential attributes, while visual image transformers (VITs) lose local semantic information. Focusing on these issues, we propose a fractional Fourier image transformer (FrIT) as a backbone network to extract both global and local contexts effectively. In the proposed FrIT framework, HSI and LiDAR data are first fused at the pixel level, and both multisource feature and HSI feature extractors are utilized to capture local contexts. Then, a plug-and-play image transformer FrIT is explored for global contextual and sequential feature extraction. Unlike the attention-based representations in classic VIT, FrIT is capable of speeding up the transformer architectures massively and learning valuable contextual information effectively and efficiently. More significantly, to reduce redundancy and loss of information from shallow to deep layers, FrIT is devised to connect contextual features in multiple fractional domains. Five HSI and LiDAR scenes including one newly labeled benchmark are utilized for extensive experiments, showing improvement over both CNNs and VITs.

Adaptive Distance-Based Band Hierarchy (ADBH) for Effective Hyperspectral Band Selection.

Band selection has become a significant issue for the efficiency of the hyperspectral image (HSI) processing. Although many unsupervised band selection (UBS) approaches have been developed in the last decades, a flexible and robust method is still lacking. The lack of proper understanding of the HSI data structure has resulted in the inconsistency in the outcome of UBS. Besides, most of the UBS methods are either relying on complicated measurements or rather noise sensitive, which hinder the efficiency of the determined band subset. In this article, an adaptive distance-based band hierarchy (ADBH) clustering framework is proposed for UBS in HSI, which can help to avoid the noisy bands while reflecting the hierarchical data structure of HSI. With a tree hierarchy-based framework, we can acquire any number of band subset. By introducing a novel adaptive distance into the hierarchy, the similarity between bands and band groups can be computed straightforward while reducing the effect of noisy bands. Experiments on four datasets acquired from two HSI systems have fully validated the superiority of the proposed framework.

Multilayer Sparsity-Based Tensor Decomposition for Low-Rank Tensor Completion.

Existing methods for tensor completion (TC) have limited ability for characterizing low-rank (LR) structures. To depict the complex hierarchical knowledge with implicit sparsity attributes hidden in a tensor, we propose a new multilayer sparsity-based tensor decomposition (MLSTD) for the low-rank tensor completion (LRTC). The method encodes the structured sparsity of a tensor by the multiple-layer representation. Specifically, we use the CANDECOMP/PARAFAC (CP) model to decompose a tensor into an ensemble of the sum of rank-1 tensors, and the number of rank-1 components is easily interpreted as the first-layer sparsity measure. Presumably, the factor matrices are smooth since local piecewise property exists in within-mode correlation. In subspace, the local smoothness can be regarded as the second-layer sparsity. To describe the refined structures of factor/subspace sparsity, we introduce a new sparsity insight of subspace smoothness: a self-adaptive low-rank matrix factorization (LRMF) scheme, called the third-layer sparsity. By the progressive description of the sparsity structure, we formulate an MLSTD model and embed it into the LRTC problem. Then, an effective alternating direction method of multipliers (ADMM) algorithm is designed for the MLSTD minimization problem. Various experiments in RGB images, hyperspectral images (HSIs), and videos substantiate that the proposed LRTC methods are superior to state-of-the-art methods.

Spatial-Spectral Structured Sparse Low-Rank Representation for Hyperspectral Image Super-Resolution.

Hyperspectral image super-resolution by fusing high-resolution multispectral image (HR-MSI) and low-resolution hyperspectral image (LR-HSI) aims at reconstructing high resolution spatial-spectral information of the scene. Existing methods mostly based on spectral unmixing and sparse representation are often developed from a low-level vision task perspective, they cannot sufficiently make use of the spatial and spectral priors available from higher-level analysis. To this issue, this paper proposes a novel HSI super-resolution method that fully considers the spatial/spectral subspace low-rank relationships between available HR-MSI/LR-HSI and latent HSI. Specifically, it relies on a new subspace clustering method named "structured sparse low-rank representation" (SSLRR), to represent the data samples as linear combinations of the bases in a given dictionary, where the sparse structure is induced by low-rank factorization for the affinity matrix. Then we exploit the proposed SSLRR model to learn the SSLRR along spatial/spectral domain from the MSI/HSI inputs. By using the learned spatial and spectral low-rank structures, we formulate the proposed HSI super-resolution model as a variational optimization problem, which can be readily solved by the ADMM algorithm. Compared with state-of-the-art hyperspectral super-resolution methods, the proposed method shows better performance on three benchmark datasets in terms of both visual and quantitative evaluation.

Enhanced Sparsity Prior Model for Low-Rank Tensor Completion.

Conventional tensor completion (TC) methods generally assume that the sparsity of tensor-valued data lies in the global subspace. The so-called global sparsity prior is measured by the tensor nuclear norm. Such assumption is not reliable in recovering low-rank (LR) tensor data, especially when considerable elements of data are missing. To mitigate this weakness, this article presents an enhanced sparsity prior model for LRTC using both local and global sparsity information in a latent LR tensor. In specific, we adopt a doubly weighted strategy for nuclear norm along each mode to characterize global sparsity prior of tensor. Different from traditional tensor-based local sparsity description, the proposed factor gradient sparsity prior in the Tucker decomposition model describes the underlying subspace local smoothness in real-world tensor objects, which simultaneously characterizes local piecewise structure over all dimensions. Moreover, there is no need to minimize the rank of a tensor for the proposed local sparsity prior. Extensive experiments on synthetic data, real-world hyperspectral images, and face modeling data demonstrate that the proposed model outperforms state-of-the-art techniques in terms of prediction capability and efficiency.

Variational Textured Dirichlet Process Mixture Model with Pairwise Constraint for Unsupervised Classification of Polarimetric SAR Images.

This paper proposes an unsupervised classification method for multilook polarimetric synthetic aperture radar (Pol-SAR) data. The proposed method simultaneously deals with the heterogeneity and incorporates the local correlation in PolSAR images. Specifically, within the probabilistic framework of the Dirichlet process mixture model (DPMM), an observed PolSAR data point is described by the multiplication of a Wishartdistributed component and a class-dependent random variable (i.e., the textual variable). This modeling scheme leads to the proposed textured DPMM (tDPMM), which possesses more flexibility in characterizing PolSAR data in heterogeneous areas and from high-resolution images due to the introduction of the classdependent texture variable. The proposed tDPMM is learned by solving an optimization problem to achieve its Bayesian inference. With the knowledge of this optimization-based learning, the local correlation is incorporated through the pairwise constraint, which integrates an appropriate penalty term into the objective function so as to encourage the neighboring pixels to fall into the same category and to alleviate the "salt-and-pepper" classification appearance.We develop the learning algorithm with all the closed-form updates. The performance of the proposed method is evaluated with both low-resolution and high-resolution PolSAR images, which involve homogeneous, heterogeneous, and extremely heterogeneous areas. The experimental results reveal that the class-dependent texture variable is beneficial to PolSAR image classification and the pairwise constraint can effectively incorporate the local correlation in PolSAR images.

High-Resolution Aerial Imagery Semantic Labeling with Dense Pyramid Network.

Semantic segmentation of high-resolution aerial images is of great importance in certain fields, but the increasing spatial resolution brings large intra-class variance and small inter-class differences that can lead to classification ambiguities. Based on high-level contextual features, the deep convolutional neural network (DCNN) is an effective method to deal with semantic segmentation of high-resolution aerial imagery. In this work, a novel dense pyramid network (DPN) is proposed for semantic segmentation. The network starts with group convolutions to deal with multi-sensor data in channel wise to extract feature maps of each channel separately; by doing so, more information from each channel can be preserved. This process is followed by the channel shuffle operation to enhance the representation ability of the network. Then, four densely connected convolutional blocks are utilized to both extract and take full advantage of features. The pyramid pooling module combined with two convolutional layers are set to fuse multi-resolution and multi-sensor features through an effective global scenery prior manner, producing the probability graph for each class. Moreover, the median frequency balanced focal loss is proposed to replace the standard cross entropy loss in the training phase to deal with the class imbalance problem. We evaluate the dense pyramid network on the International Society for Photogrammetry and Remote Sensing (ISPRS) Vaihingen and Potsdam 2D semantic labeling dataset, and the results demonstrate that the proposed framework exhibits better performances, compared to the state of the art baseline.

An Occlusion-Robust Feature Selection Framework in Pedestrian Detection †.

Better features have been driving the progress of pedestrian detection over the past years. However, as features become richer and higher dimensional, noise and redundancy in the feature sets become bigger problems. These problems slow down learning and can even reduce the performance of the learned model. Current solutions typically exploit dimension reduction techniques. In this paper, we propose a simple but effective feature selection framework for pedestrian detection. Moreover, we introduce occluded pedestrian samples into the training process and combine it with a new feature selection criterion, which enables improved performances for occlusion handling problems. Experimental results on the Caltech Pedestrian dataset demonstrate the efficiency of our method over the state-of-art methods, especially for the occluded pedestrians.

Group Sparse Representation Based on Nonlocal Spatial and Local Spectral Similarity for Hyperspectral Imagery Classification.

Spectral-spatial classification has been widely applied for remote sensing applications, especially for hyperspectral imagery. Traditional methods mainly focus on local spatial similarity and neglect nonlocal spatial similarity. Recently, nonlocal self-similarity (NLSS) has gradually gained support since it can be used to support spatial coherence tasks. However, these methods are biased towards the direct use of spatial information as a whole, while discriminative spectral information is not well exploited. In this paper, we propose a novel method to couple both nonlocal spatial and local spectral similarity together in a single framework. In particular, the proposed approach exploits nonlocal spatial similarities by searching non-overlapped patches, whereas spectral similarity is analyzed locally within the locally discovered patches. By fusion of nonlocal and local information, we then apply group sparse representation (GSR) for classification based on a group structured prior. Experimental results on three real hyperspectral data sets demonstrate the efficiency of the proposed approach, and the improvements are significant over the methods that consider either nonlocal or local similarity.