RESUMO
The polymorphism of the TNF A gene was studied in 89 asthmatic patients and their 162 relatives in order to estimate the contribution of this candidate gene to the predisposition to the development of asthma and allergic diseases. A control group comprised 258 individuals without bronchopulmonary pathology The polymerase chain reaction was used to study the 308 G/A polymorphism of the TNF A gene. The findings suggest that the asthmatic patients and their relatives have no association of the polymorphism of the TNF A gene in position 308 with their predisposition to the disease. Analysis of the distribution of the frequencies of alleles and genotypes among their probands, relatives, and the control group revealed no statistically significant differences between the groups.
Assuntos
Asma/genética , DNA/genética , Família , Predisposição Genética para Doença , Polimorfismo Genético , Fator de Necrose Tumoral alfa/genética , Adulto , Alelos , Asma/sangue , Feminino , Frequência do Gene , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Fator de Necrose Tumoral alfa/sangueRESUMO
A familial survey was conducted in 81 probands who were diagnosed as having bronchial asthma (BA) and their 183 first-, second-, and third-degree relatives (a study group). A control group comprised 263 apparently healthy individuals. The familial accumulation of BA was ascertained in the families of probands with this condition. Autosomal dominant inheritance of BA was established. The heterozygous variant of the macrophage-colony-stimulating factor receptor (MCSFR) gene genotype chi-fms may be considered as one of the genetic predictors of BA. The homozygous genotype in a rare allele of the MCSFR gene may be also a predictor of BA.
