Three-dimensional radiographic assessment of different fixation methods stability after l-shaped osteotomy reduction malarplasty: A comparative retrospective study.

BACKGROUND: Reduction malarplasty (RM) is a common facial contouring procedure among Orientals. Currently, fixation methods selection and placement vectors are controversial. Therefore, this study aimed to evaluate the effect of different zygomatic complex fixation methods on surgical outcomes stability after RM. MATERIALS AND METHODS: In this retrospective study, 60 consented patients (120 operated zygoma) who met inclusion criteria were included. ITK-SNAP and 3D Slicer software were used to measure the displacement of the zygomatic complex using postoperative CTs (T1: one week and T2: six months). The region of interest included zygomatic body fixation methods (ZBFm), namely: two bicortical screws (2LS); an l-shaped plate with one bicortical screw (LPLS); an l-shaped plate with short-wing on the zygoma (LPwZ) and on the maxilla (LPwM), combined with zygomatic arch fixation methods (ZAFm), including Mortice-Tenon (MT); 3-hole plate (3HP); and short screw (SS). ANOVA test was used to compare the displacement values among ZBFm/ZAFm combinations. RESULTS: The 2LS and LPLS groups showed lower displacement than the single l-shaped plate (P< 0.001, P = 0.001), which performed better when the short-wing was fixated on the maxilla (0.9 ± 0.4 mm and 1.2 ± 0.6 mm respectively). CONCLUSION: After RM, the two-bridge fixation methods (2LS and LPLS) provide better stability than the single l-shaped plate. All ZAF methods showed similar stability when combined with 2LS or LPLS as zygomatic body fixation methods.

Correction of hemifacial microsomia using preformed titanium mesh combined with contralateral mandibular angle bone graft with CAD/CAM assistance / 口腔医学

@#Objective To explore the indications and clinical effects of simultaneous mandibular angleplasty on the unaffected side, performed using preformed titanium mesh combined with mandibular angle bone graft, for the treatment of hemifacial microsomia (HFM). Methods The study group included 11 patients between 2013 and 2021 with HFM who underwent simultaneous mandibular angle reduction of the unaffected side and augmentation of the affected side using resected bone scaffolds within the titanium mesh. A series of mandibular linear measurements such as ramus height(RH)and mandibular body length(BL), angular measurements, and asymmetry index combined with clinical photographs and postoperative complications were used to assess the therapeutic effect. Results Postoperatively, all patients were satisfied. Significant improvement in mandibular contour was shown, with no obvious complications. Postoperative data, such as BL and angular measurements, showed no statistically significant differences(P>0.05) between the affected and unaffected sides with improvement in symmetry, except for RH(P<0.05). The preoperative and postoperative asymmetry index were (17.11±4.56)% and (4.81±1.73)%, respectively, with significant improvement(P=0.002). Conclusion This approach provides satisfactory results and significantly improves facial asymmetries for unilateral HFM with hypertrophy of the contralateral mandibular angle.

Genome-wide isoform-level analysis reveals tumor-specific isoforms for lung adenocarcinoma diagnosis and prognosis.

Last decades have witnessed the great progress in exploration of tumor transcriptome. However, most researches were restricted in gene-level expression. mRNA isoforms, especially tumor-specific isoforms have not been fully explored in tumor. Here, by analyzing RNA-seq data derived from hundreds of samples in TCGA projects, we comprehensively characterized the expression variations of mRNA isoforms in adenocarcinoma of lung (LUAD), which is one of leading causes of cancer-related death. Our analysis found that a variety of mRNA isoforms showed differential expression in LUAD tumor samples. Some of them even showed distinct variations compared to their host genes. Further analysis of functional enrichment revealed that up- and down-regulated mRNA isoforms took part in different types of biological process. In addition, we also identified hundreds of isoforms that expressed exclusively in LUAD tumor samples. Furthermore, the expression level of several isoforms, such as uc001kuk.3 and uc003yls.2, could separate tumor patients by overall survival periods. Our study provided new candidates for the diagnosis and prognosis of lung cancer.