[Rational combinations of hormonal and cytostatic agents in disseminated forms of breast cancer]. / O ratsional'nykh kombinatsiiakh gormonal'nykh i tsitostaticheskikh sredstv pri disseminirovannykh formakh raka molochnoo zhelezy.

The report deals with the results of chemotherapy of 25 cases of advanced breast cancer. The patients had received tamoxifen + diethylstilbestrol (or chlorotrianizen) to stimulate a short-term proliferation in tumor and to potentiate the effect of cytostatic drugs. Complete regression of tumor was observed in I case and partial regression--in 12 cases (overall response--52%). Tumor growth stimulation effect was assessed on the basis of changes in DNA synthesis rate and proliferative pool as evidenced by repeated biopsy of tumor.