POSS-Based Polymers.

The combination of functional polymers with inorganic nanostructured compounds has become a major area of research and technological development owing to the remarkable properties and multifunctionalities deriving from their nano and hybrid structures [...].

The thrombogenic activity of POSS silanols.

In vitro studies into the interaction of polyhedral oligomeric silsesquioxane (POSS) trisilanols with porcine and human red blood cells (erythrocytes), and mouse fibroblasts is reported. The observations are in agreement with previously reported erythrocyte activity of silanol containing minerals. However the multifunctionality imparted by the POSS silanols provides for their expansion of utility in traumatic hemorrhage and wound care. Further, in vitro tissue studies of i-octyltrisilanol POSS cages are in agreement with reported findings of related POSS serving as tissue scaffolds by providing cellular binding sites and porosity for cellular taxis. The resulting effect is increased rates of tissue healing.