Assuntos
Aminofilina/farmacocinética , Animais Recém-Nascidos/metabolismo , Cabras/metabolismo , Inibidores de Fosfodiesterase/farmacocinética , Administração Oral , Aminofilina/administração & dosagem , Aminofilina/farmacologia , Animais , Peso ao Nascer/efeitos dos fármacos , Feminino , Meia-Vida , Injeções Intravenosas/veterinária , Masculino , Inibidores de Fosfodiesterase/administração & dosagem , Inibidores de Fosfodiesterase/farmacologiaAssuntos
Doenças do Cão/diagnóstico , Dispneia/veterinária , Acalasia Esofágica/veterinária , Pneumonia Aspirativa/veterinária , Animais , Cães , Dispneia/diagnóstico , Dispneia/etiologia , Acalasia Esofágica/diagnóstico , Esôfago/patologia , Humanos , Pulmão/patologia , Pneumonia Aspirativa/diagnóstico , Pneumonia Aspirativa/patologiaRESUMO
We describe a new deafness mutant found in the Zucker rat. The mutant phenotype appears to be caused by an autosomal recessive gene, tentatively named stargazer, gene symbol stg. The phenotype is characterized by stargazing, head tossing, drawing back, circling, and hyperactivity, all of which are apparent by the third week of life. Although the affected animals sire or bear normal-sized litters, mortality is high for litters of affected dams, apparently due to trampling or neglect by the hyperactive dams. Affected animals are unable to swim and, when lifted by the tail, they are likely to curl ventrally, rather than extending their paws downward. These behaviors are consistent with a disorder of the vestibular system. Auditory evoked potential recordings were attempted as a hearing test. The failure of audible clicks up to 90 decibels to stimulate the auditory tract indicates that stargazers are profoundly deaf. These disruptions of vestibular and auditory systems suggest that the stargazer phenotype may be caused by disordered development of the inner ear. Histologic examination of the inner ear revealed progressive degeneration of cells in the acoustic ganglion and of hair cells. The stargazer rat may be useful as a model for hereditary deafness or hyperactivity.
Assuntos
Surdez/veterinária , Mutação , Ratos Zucker/genética , Doenças dos Roedores/genética , Animais , Comportamento Animal , Cóclea/patologia , Cruzamentos Genéticos , Surdez/genética , Surdez/patologia , Modelos Animais de Doenças , Potenciais Evocados Auditivos , Feminino , Masculino , Fenótipo , RatosAssuntos
Doenças das Aves/etiologia , Columbidae , Enterite/veterinária , Complexo Vitamínico B/uso terapêutico , Deficiência de Vitaminas do Complexo B/veterinária , Animais , Doenças das Aves/tratamento farmacológico , Doenças das Aves/patologia , Cistos/tratamento farmacológico , Cistos/veterinária , Enterite/tratamento farmacológico , Enterite/etiologia , Feminino , Deficiência de Vitaminas do Complexo B/complicações , Deficiência de Vitaminas do Complexo B/patologiaRESUMO
Seven purebred Toggenburg fetuses in four does, six purebred Nubian fetuses in four does, and eight Angora fetuses in six does were repeatedly measured using transabdominal real-time ultrasound with a 5 MH(z) linear-array transducer from 40 d to 100 d gestational age (GA) and their biparietal diameters (BPD) were determined. For Toggenburg goats the GA = 27.9 + 1.64 BPD; for Nubian goats the GA = 26.8 + 1.74 BPD; for Angora goats the GA = 28.6 + 1.77 BPD. The breed differences in GA for equal BPD are insignificant at the beginning of the second trimester but are +3 d for Nubian and +6 d for Angora fetuses by the end of the second trimester.
