1.
J Org Chem
; 65(5): 1399-406, 2000 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10814101
RESUMO
A practical large-scale synthesis of the naphthosultam-based side chain of the anti-MRSA antibiotic 1 has been achieved in 29% overall yield over seven steps from 1-methylnaphthalene. The synthesis was completed without the use of protecting groups, featuring a novel naphthosultam annelation, a chemoselective acid-catalyzed triflation, and the use of a novel naphthosultam dianion to effect functionalization through benzylic metalation.