1.
Bioorg Med Chem Lett
; 11(5): 733-6, 2001 Mar 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11266180
RESUMO
Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.