1.
Bioorg Med Chem Lett
; 13(10): 1705-8, 2003 May 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12729646
RESUMO
The synthesis and activity of novel benzothiophene derivatives are described. In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC(50). This class of compounds potentially represents a new generation of antithrombotic-fibrinolytic agents.