1.
J Antimicrob Chemother
; 69(6): 1725-6, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24722835
2.
J Antimicrob Chemother
; 69(6): 1723-4, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24569629
3.
Antimicrob Agents Chemother
; 57(2): 1040-6, 2013 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23165468
RESUMO
Avermectins are a family of macrolides known for their anthelmintic activities and traditionally believed to be inactive against all bacteria. Here we report that members of the family, ivermectin, selamectin, and moxidectin, are bactericidal against mycobacterial species, including multidrug-resistant and extensively drug-resistant clinical strains of Mycobacterium tuberculosis. Avermectins are approved for clinical and veterinary uses and have documented pharmacokinetic and safety profiles. We suggest that avermectins could be repurposed for tuberculosis treatment.